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Ratecontrolled and sitespecific rectal drug delivery Scope
Osmotic drug delivery system in vitro and in vivo charac
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afgifte ALZA Corporation amount antipyrine anus aqueous avoidance of first-pass bioavailability Biopharm Blood samples Boer calculated cannula choline theophyllinate clearance Clin concentration time curves crosslinker D. D. Breimer dosage form dose drug concentration drug delivery system drug release drug solution EGDMA elimination half-lives etomidate farmaca following rectal hepatic high-clearance drugs hydrogel preparation i.v. administration intravenous isoproterenol Leede Leiden lidocaine HC1 mean metabolism metabolite mg/ml oral administration orifice osmotic delivery system osmotic pump osmotic system Pharm pharmacokinetic Pharmacol plasma plasma and saliva plasma concentration polymerization presystemic elimination propranolol propranolol administration propranolol concentration ratio rats rectal administration rectal drug administration rectal drug delivery rectal infusion rectal route rectale toediening rectum release profile route of administration saliva saliva concentration site-specific rectal drug subjects suppository systemic availability Theeuwes theophylline concentration trapezoidal rule triazolam University of Leiden urine vitro vitro release vivo werd wordt zero-order release rate