Guide for Laboratory Animal Facilities and Care

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U.S. Department of Health, Education, and Welfare, Public Health Service, 1965 - Laboratory animals - 45 pages

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Page 5 - ... and reasonably expected to be present in such feed or water are not present at levels above those specified in the protocol. Documentation of such analyses shall be maintained as raw data. (h) Bedding used in animal cages or pens shall not interfere with the purpose or conduct of the study and shall be changed as often as necessary to keep the animals dry and clean.
Page 22 - ... activities from animal rooms to areas specifically designed for this purpose. The use of sound-reducing materials in animal rooms can be helpful. Concrete walls are more effective than metal or plaster walls in containing sound because density is more important than acoustical materials in reducing the transmission of sound. Acoustical materials may be used in animal rooms by direct application to the ceiling, or as part of a suspended ceiling, providing the rooms are vermin-proof. The elimination...
Page 18 - Ceilings Ceilings formed by the concrete floor above are satisfactory if properly smoothed, sealed, and painted. Furred ceilings of plaster or fire code plasterboard should be sealed and painted with a washable finish. Exposed pipes and fixtures at ceiling level are undesirable, especially in nonhuman primate rooms, because of the problems created by escaped animals.
Page 3 - The caging or housing system is perhaps the most important single element in the physical environment for laboratory animals. Inasmuch as the well-being of the animals and the control of experiments are influenced by the housing system, it should always be designed carefully. The following criteria may be used to evaluate the...
Page 6 - Vermin control programs should be instituted in new buildings prior to occupancy. Effective control and ultimate elimination can be attained in older buildings, even where heavy infestation has occurred. This can be accomplished by sealing or eliminating all breeding sites, and by using pesticides or trapping procedures in conjunction with a strict program of sanitary maintenance. Pesticide application must be carried out under professional supervision in order to avoid toxic effects on the animals...
Page 21 - ... turnover. Bulk supplies of food and bedding should not be stored in animal rooms. A separate area or room should be available in which food and bedding can be stored off the floor on pallets, racks, or carts. A continuing pest control program is essential. It is most desirable for the storage areas to be vermin-proof. Food storage areas should be physically separated from refuse areas. Temperatures in the storage rooms may be the ambient temperature. However, it is good practice to hold packaged...
Page 23 - A machine for washing bottles and sipper tubes is recommended if large numbers of water bottles are used. Some cage-washing machines may also be used for this purpose. If bottles are washed by hand, powered rotating brushes located at the washing sink are useful. If hand washed, provision should be made for dipping or soaking water bottles in detergent and disinfectant solutions. A two-compartment sink or tub is adequate for this purpose.
Page 18 - If windows are provided, it is preferable that they be nonopening, without sills or horizontal surfaces where dust can collect, of an insulating construction (in areas of temperature extremes) , and sealed with a material that will withstand repeated washing and disinfecting. If windows are opened for ventilation purposes, effective screening is essential. 4. Floors Floors should be smooth, waterproof, nonabsorbent, nonslip, wear resistant, acid and solvent resistant, capable of being scrubbed with...

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