Sex-Specific Analysis of Cardiovascular Function

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Peter L. M. Kerkhof, Virginia M. Miller
Springer, Jul 26, 2018 - Medical - 725 pages

This book gathers together contributions from internationally renowned authors in the field of cardiovascular systems and provides crucial insight into the importance of sex- and gender-concepts during the analysis of patient data. This innovative title is the first to offer the elements necessary to consider sex-related properties in both clinical and basic studies regarding the heart and circulation on multiscale levels (i.e. molecular, cellular, electrophysiologically, neuroendocrine, immunoregulatory, organ, allometric, and modeling). Observed differences at (ultra)cellular and organ level are quantified, with focus on clinical relevance and implications for diagnosis and patient management. Since the cardiovascular system is of vital importance for all tissues, Sex-Specific Analysis of Cardiovascular Function is an essential source of information for clinicians, biologists, and biomedical investigators. The wide spectrum of differences described in this book will also act as an eye-opener and serve as a handbook for students, teachers, scientists and practitioners.

 

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Contents

Women and Men in the History of Western Cardiology Some Notes on Their Position as Patients Role as Investigation
1
An Introduction to Epigenetics in Cardiovascular Development Disease and Sexualization
31
Epidemiology of Congenital Heart Disease with Emphasis on SexRelated Aspects
48
Sex Differences in Epidemiology of Cardiac and Vascular Disease
61
Biostatistics in Cardiovascular Research with Emphasis on SexRelated Aspects
71
The Influence of Age and Sex on the Electrocardiogram
93
Safety and Effectiveness of Medical Device Therapy
107
Cardiophysiology Illustrated by Comparing Ventricular Volumes in Healthy Adult Males and Females
122
Heart Function Analysis in Cardiac Patients with Focus on SexSpecific Aspects
361
Heart Transplantation Survival and SexRelated Differences
379
Differences in Cardiovascular Aging in Men and Women
389
Hemodynamic and Electrocardiographic Aspects of Uncomplicated Singleton Pregnancy
413
SexSpecific Physiology and Cardiovascular Disease
433
Cardiovascular Sequels During and After Preeclampsia
455
Cardiovascular Implications of Diabetes Metabolic Syndrome Thyroid Disease and CardioOncology in Women
471
SexSpecific Cardiovascular Comorbidities with Associations in Dermatologic and Rheumatic Disorders
489

Sex Differences in Regulation of Blood Pressure
139
Arterial Flow Pulse Pressure and Pulse Wave Velocity in Men and Women at Various Ages
153
Wave Intensity Analysis SexSpecific Differences in Hemodynamic and Ventilatory Responses to Graded ExerciseEcho
169
Sex Differences in Autonomic Response to Exercise Testing in Patients with Brugada Syndrome
181
Benchmarking Heart Rate Variability to Overcome SexRelated Bias
191
Cardiovascular Allometry Analysis Methodology and Clinical Applications
207
The Heart as a Psychoneuroendocrine and Immunoregulatory Organ
225
Mitochondria and SexSpecific Cardiac Function
241
Sex Differences in the Coronary System
257
Cerebral Circulation in Men and Women
279
Arterial Wall Properties in Men and Women Hemodynamic Analysis and Clinical Implications
291
SexSpecific Characteristics of the Microcirculation
307
SexSpecific Ventricular and Vascular Adaptations to Exercise
329
Growth of Cardiovascular Structures from the Fetus to the Young Adult
347
The Role of Sex in the Pathophysiology of Pulmonary Hypertension
510
Sex Differences in Heart Failure
529
SexRelated Aspects of Biomarkers in Cardiac Disease
545
Cardiac Rehabilitation for Women
565
Stroke Rehabilitation Therapy Robots and Assistive Devices
579
Precision Medicine and Personalized Medicine in Cardiovascular Disease
588
BigData Analysis Cluster Analysis and MachineLearning Approaches
607
GenomeWide Association Studies and Risk Scores for Coronary Artery Disease Sex Biases
627
Gendered Innovation in Health and Medicine
643
Gendered Innovations in the Study of Cardiovascular Diseases
655
Sex and AgeRelated Reference Values in Cardiology with Annotations and Guidelines for Interpretation
677
Index
707
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About the author (2018)

Peter L. M. Kerkhof, Studying at Leiden University, Peter LM Kerkhof completed his PhD thesis on clinical physiology (Dept. Pediatrics). His novel approach to analyzing cardiac pump function won him a Young Investigator’s Award at the World Congress of Cardiology, Moscow, 1982. As an NIH Fogarty Fellow he joined Harvard Medical School, and next Bioengineering at the University of Pennsylvania. He was organizer and chairman of the VIth International Meeting on Clinical Laboratory Organization and Management, The Netherlands, 1987. At AMA in Chicago he was Distinguished Lecturer in Medical Science in 1990, and at Rutgers University in 1996 visiting professor in Bioengineering. For two decades he served as associate editor of IEEE Trans BME, and acted as guest editor. He edited three books, and published on cardiology and medical informatics. While interested in computer assisted diagnosis, he is also associated with Radiology and Nuclear Medicine, VUMC, Amsterdam, where his focus is on pediatric cardiology, heart transplantation, and sex-related issues in heart failure.

Virginia M. Miller, PhD, is Professor of Surgery and Physiology and Director of the Women’s Health Research Center at Mayo Clinic, Rochester, MN. Trained as a comparative physiologist at the University of Missouri, Columbia, MO, her work has spanned basic studies of temperature regulation in hibernating animals, brain pathways involved with spatial memory, hormonal influences on the vascular endothelium and platelets in experimental animals to sex-specific risk (i.e. hypertensive pregnancy disorder, oophorectomy and natural menopause) for vascular dysfunction and cognitive decline in women. Her interdisciplinary approach to promoting research in sex differences has won her several awards including the Bernadine Healy Award for Visionary Leadership in Women’s Health and the Women’s Day Magazine Red Dress Award for promoting heart health in women. Topics in this book reflect her passion for mentoring the next generation of basic and clinical scientists to fill the knowledge gaps in understanding how biological sex influences health and disease.

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