Antibiotics and Chemotherapy, Volume 31; Volume 34 |
Contents
Metabolism of Sulfonamides | 5 |
The AcetylationDeacetylation Equilibrium | 11 |
Relationships between Molecular Structure and Acetylation | 31 |
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Common terms and phrases
acetylation-deacetylation equilibrium acetylator phenotype acid active tubular secretion administration animals clin cows creatinine clearance crystalluria curves and renal dimidine enzyme excr excretion rate-time profiles fast gene glomerular filtration glucuronide h Fig half-life Hekster hydroxy hydroxy metabolites hydroxylation impaired kidney function intrinsic half-life inulin merazine metab metabolic pathway metabolite metabolite N4-acetylsulfamethoxazole methoxazole mg sulfamethoxazole mg/kg ml/min N4-acetyl derivative N4-acetyl metabolite N4-acetylsul N4-acetylsulfadimidine N4-acetylsulfamerazine N4-acetylsulfamethoxazole N4 N4-acetylsulfametrole parameters of sulfonamides parent compound parent drug patients with impaired percentage Pharm pharmacokinetic pharmacokinetic parameters Pharmacol Plasma conc plasma concentration Plasma concentration-time curves plotted versus probenecid profiles of sulfamethoxazole Prot protein binding rate of acetylation renal clearance values renal excretion rate renal excretion rate-time SCH2OH shown in figure slow species Sulfadiazine Sulfadimethoxine sulfadimidine Sulfadoxine Sulfafurazole sulfamerazine sulfamethizole Sulfamethomidine sulfamethoxazole Sulfamethoxypyridazine sulfametrole Sulfamonomethoxine sulfamoxole Sulfanilamide Sulfaphenazole Sulfapyridine Sulfathiazole sulfatroxazole Sulfisomidine sulfon sulfonamides Table tion trimethoprim urine urine flow urine pH Vree µg/min