Cell Biology and Immunology of Leukocyte FunctionMichael R. Quastel Cell Biology and Immunology of Leukocyte Function is a collection of papers presented at the 12th International Leukocyte Culture Conference, held in Beersheba, Israel on June 1978. This book is organized into seven parts encompassing 111 chapters. The contributors cover the different aspects of cell biology and immunology and the unique leukocyte function. Part I describes the mechanism of lymphocyte activation, the structure and function of the plasma membrane, and the macromolecular synthesis during lymphocyte activation. This part also deals with the interaction of lymphocytes with mitogenic lectins, the comparison of the mitogenic and nonmitogenic lectin binding, and the role of macrophages in the response of lymphocytes to lectins. Part II explores the thymic factors and the development of characteristic markers, antigens, and receptors. This part particularly emphasizes lymphocyte differentiation. Parts III and IV examine the genetic control and intercellular interactions involved in leukocyte function and the parameters of the immune response under in vitro conditions. Chapters on cytotoxicity, the mechanisms of phagocytic killing, autoimmunity, and the responses of leukocytes to tumor cells are included in these parts. Part V discusses the interactions of viruses and leukocytes and provides data on the physical mapping and analysis of sarcoma and leukemia viruses, while Part VI considers the application of leukocyte culture to problems of clinical medicine. Part VII involves the study of radiation effects, with an emphasis on the application of total lymphoid irradiation to the induction of transplantation tolerance. This part also looks into the role of the DNA repair process. Cell biologists, immunologists, and biomedical scientists and researchers will greatly benefit from this book. |
Contents
The Lymphocyte Membrane and the Cytoskeleton | 3 |
Triggering Signals for TCell Activation | 11 |
Studies of Lymphocyte Activation 27 | 27 |
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Common terms and phrases
1979 by Academic Acad Academic Press acid activity alloantigens allogeneic anti antibody antigen assay BALB/c binding Ca2+ Cancer cell populations cell surface cellular concentrations culture cytes cytotoxic differentiation donor dose effect effector cells enzyme experiments factor form reserved fraction function gene helper T cells human Ia antigens idiotype immune response Immunol Immunology increase incubated induced inhibition inhibitory injected interaction interferon ISBN Israel lectins lymph node lymphocytes lymphoid lymphokines lysis macrophages mediated mice mitogenic molecules monocytes mouse mRNA normal ouabain patients precursor present Proc produce protein receptors Rehovot responding cells rights of reproduction rosettes sensitized serum shown specific spleen cells SRBC stimulation strain studies supernatants suppression suppressor cells syngeneic synthesis T-cells Table target cells tested thymic thymocytes thymosin thymus tion tumor tumor cells uptake virus vitro vivo