Allostasis, Homeostasis, and the Costs of Physiological AdaptationJay Schulkin, Research Professor of Physiology and Biophysics Jay Schulkin The concept of homeostasis is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. This book, the first edited volume to focus on allostasis, orients the reader by addressing basic physiological regulatory systems, and examining bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will appeal to graduate students, medical students, and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology. |
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Contents
| 17 | |
| 65 | |
| 99 | |
| 113 | |
Drug Addiction and Allostasis | 150 |
Adaptive Fear Allostasis and the Pathology of Anxiety and Depression | 164 |
A Chronobiological Perspective on Allostasis and its Application to Shift Work | 228 |
Allostatic Load and Life Cycles Implications for Neuroendocrine Control Mechanisms | 302 |
Viability as Opposed to Stability An Evolutionary Perspective on Physiological Regulation | 343 |
Index | 365 |
Other editions - View all
Allostasis, Homeostasis, and the Costs of Physiological Adaptation Jay Schulkin Limited preview - 2004 |
Allostasis, Homeostasis, and the Costs of Physiological Adaptation Jay Schulkin No preview available - 2012 |
Common terms and phrases
activity adaptation addition Aging allostasis allostatic load allostatic overload amygdala animals anxiety associated behavior biological biomarkers blood pressure body brain cells central challenges changes chronic circadian concept contribute cortex corticosterone cortisol cycle daily demand depression disease disorders drug effects elevated emotional energy environment et al example experience expression factors fear Figure function gene glucocorticoids glucose homeostasis homeostatic hormone human immune important increased indicate individual internal involved lateral learning levels maintain McEwen measured mechanisms mediators memory metabolic negative neural neurons Neurosci night normal nucleus organism patterns physiological prediction Press processes produce range rats receptors reduce regulation release response result rhythms risk role Schulkin scoring setpoint shift signals sleep social specific stages Sterling stress studies suggest temperature term tion University Wingfield York
Popular passages
Page 49 - The man whose whole life is spent in performing a few simple operations, of which the effects, too, are perhaps always the same, or very nearly the same, has no occasion to exert his understanding, or to exercise his invention, in finding out expedients for removing difficulties which never occur. He naturally loses, therefore, the habit of such exertion, and generally becomes as stupid and ignorant as it is possible for a human creature to become.
Page 50 - We felt very nice and snug, the more so since it was so chilly out of doors; indeed out of bed-clothes too, seeing that there was no fire in the room. The more so, I say, because truly to enjoy bodily warmth, some small part of you must be cold, for there is no quality in this world that is not what it is merely by contrast. Nothing exists in itself...
Page 154 - Diagram showing stages of impulse control disorder and compulsive disorder cycles related to the sources of reinforcement. In impulse control disorders an increasing tension and arousal occurs before the impulsive act, with pleasure, gratification or relief during the act. Following the act there may or may not be regret or guilt. In compulsive disorders, there are recurrent and persistent thoughts (obsessions) that cause marked anxiety and stress followed by repetitive behaviors (compulsions) that...
Page 225 - Swanson, LW, Sawchenko, PE, Rivier, J., and Vale, WW (1983). Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: An immunohistochemical study.
Page 286 - Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans.
Page 13 - Bauman, DE and WB Currie. 1980. Partitioning of nutrients during pregnancy and lactation: A review of mechanisms involving homeostasis and homeorhesis.
Page 162 - Erb, S., Salmaso, N., Rodaros, D., and Stewart, J. (2001). A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats. Psychopharmacology (Berl.) 158, 360-365.
References to this book
Measuring Stress in Humans: A Practical Guide for the Field Gillian H. Ice,Gary D. James Limited preview - 2006 |
Bibliographic information
| Title | Allostasis, Homeostasis, and the Costs of Physiological Adaptation |
| Editors | Jay Schulkin, Research Professor of Physiology and Biophysics Jay Schulkin |
| Edition | illustrated |
| Publisher | Cambridge University Press, 2004 |
| ISBN | 0521811414, 9780521811415 |
| Length | 372 pages |
| Subjects | › › Medical / Physiology Science / Life Sciences / Biophysics |
| Export Citation | BiBTeX EndNote RefMan |