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Problems in the Estimation of Mutation Rates from Evolutionary
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Acad Academic Press affected males alleles amino acid analysis APRT ascertainment autosomal bands Birth Defects Institute breakage breakpoints calculated carrier carrier test Center changes Chromosome Registry clinical codon cultures cytogenetic detected diagnosis distribution dose Down's syndrome Drosophila E.B. Hook effects electrophoretic enzyme erythrocytes estimate females fibroblasts frequency frozen-thawed gamete gene genetic genotypes germ cells globin haplotype hemoglobin hemophilia heterozygotes heterozygous HPRT HUMAN MUTATION hybrids individuals induced infants irradiation J.V. Neel labeled nuclei laboratories lethal livebirths loci locus malformations maternal age Medical mothers mouse muscular dystrophy muta mutagenic mutation rates normal novo nucleotide observed occur Patau's syndrome PBL Vf pedigree Percent phenotype polymorphism probands Proc proportion protein radiation recombination reported risk Robertsonian translocations sample SCE induction selection sequences sibships somatic cells specific spontaneous mutation structural rearrangements studies substitutions Table tests tion variants vitro X-linked York