The central purpose of this book is to illustrate the premise that examination of the kinetics of biological processes can give valuable information concerning the underlying mechanisms that are responsible for these processes. Topics covered range from cooperativity in protein binding, through receptor-infector coupling, to theories of biochemical oscillations in yeast and slime mold. In addition, an introduction to the explosively growing theoretical topic of chaos details attempts to apply this theory in physiology. The material in this book originally appeared as part of the volume Mathematical Models in Molecular and Cellular Biology (edited by Lee A. Segel and now out of print). Each article has been revised and updated.
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Allosteric and inducedfit theories of protein binding
Graphical representations for tetramer binding
Levitzki Alexander The Hebrew University of Jerusalem
Molecular models for receptor to adenylate cyclase
Models for oscillations and excitability in biochemical
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Acad actinomycin adenosine adenylate cyclase adenylate cyclase activation allosteric amplitude analysis assumption binding Biol cAMP pulses cAMP signaling system cells cellular complex concentration curve cyclic AMP cycloheximide decay of facilitation decrease dependence Dictyostelium discoideum dimer dissociation domain effector end-plate potential enzyme activation equations equilibrium excitable experimental exponential extracellular cAMP Gerisch glycolytic oscillations Goldbeter Gpp(NH)p hepatectomy Hess hormone increases induction inhibition inhibitor interaction kinetics ligand limit cycle liver Martiel mechanism membrane metabolic mitosis mitotic mmole I"1 molecule negative cooperativity nucleotide nullcline observed obtained operon oscillations period PFK reaction phase plane phosphodiesterase phosphofructokinase Physiol plot predicts protein Rahamimoff rate constant receptor regeneration regulation relay repressor saturation function Scatchard Scatchard plot Segel shown in Figure sigmoid nullcline slime mold slope stable steady subunits sustained oscillations synthesis theoretical Tolkovsky & Levitzki trajectories transmitter release yeast