UICC Workshop on Drug Resistance and Selectivity in Cancer Chemotherapy, Bratislava, Czechoslovakia, July 7-8, 1975: a report
Enrico Mihich, International Union against Cancer. Committee on International Collaborative Activities
International Union Against Cancer, 1976 - Medical - 37 pages
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activity adenosine alkylating agents antimetabolites antitumor agents araC asparaginase Bertino binding biochemical biosynthesis Cancer cell kill cell lines cell populations cells in culture cellular uptake CF rescue chemotherapy clinical compounds concentrations correlation cytotoxicity damage dATP dCTP deaminase decrease determinants of drug dGTP differences in sensitivity dihydrofolate reductase DNA polymerase DNA synthesis dNTP dNTP pools doses of MTX drug action dTTP echinomycin effects of MTX enzyme example folate FUdR Grindey growth rate Hakala Harrap hepatoma human tumor increased inhibition of DNA inhibitors intercalation intracellular IPAR leukemia mechanisms metabolic metabolites metastases mice natural resistance novo pathways nucleo nucleotide nucleotide pools plasma membrane pools profile possibility protein PRPP purine pyrimidine ribonucleotide Rustum salvage pathways samples Schwartz selectivity of drug specific studies substrate Taper hepatoma target cells target enzyme Tattersall thymidine kinase toxicity transport triphosphate tumor and normal tumor cells UICC unpublished data vitro Walker tumor