Epidermal Cell Population Kinetics in Chemically Induced Hyperplasia |
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Contents
INTRODUCTION | 9 |
EXPERIMENTS AND RESULTS | 37 |
DISCUSSION OF THE METHOD | 53 |
Copyright | |
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0.6 per cent 14 days agents alterations animals appeared application of benzene application of cantharidin application of methylcholanthrene applications of 3-4 arrested mitoses basal cells best fit Bullough Cancer cantharidin in benzene carcinogens cation cell loss cell proliferation cent cantharidin cent methylcholanthrene chalone changes colchicine cybernetic decrease differentiating cells discussed distribution dividing division dose drops of benzene effect epidermal cell population epidermis estimated evident examined experimental period experiments fairly fluctuations followed groups growth hairless histological hyperplasia increased indicate Init.magn initial injection of colcemid killed later line of best maturing Mean mitotic SD mentioned method methylcholanthrene in benzene mice mitotic count mitotic duration mitotic rate mouse normal range observed oscillations possible present study probably produced prolonged reaction regard repeated applications represents rise seen short shown single application skin standard stimulating substance suggest Table tissue treated tumours values variations weekly weeks