Mitochondrial Function and Dysfunction
Elsevier, Jan 10, 2003 - Medical - 559 pages
Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease.
* Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction
* Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases
* Includes outstanding list of contributing authors
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PRIMARY RESPIRATORY CHAIN DISORDERS
SECONDARY RESPIRATORY CHAIN DISORDERS
TOXININDUCED MITOCHONDRIAL DYSFUNCTION
MODELS OF MITOCHONDRIAL DISEASE
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abnormalities Acad activity Alzheimer’s disease apoptosis associated ataxia autosomal Beal binding biochemical Biol Biophys brain calcium carnitine cell lines cellular Chem chondrial chromosome clinical coenzyme Q10 complex copper COX deficiency cybrid cytochrome oxidase cytosolic defect dehydrogenase deletions DiMauro disorders domain dopamine drial electron encoded enzyme excitotoxic fatty acids fibroblasts frataxin FRDA free radical Friedreich’s ataxia function Genet genome human huntingtin Huntington’s disease impaired increased inhibition inner membrane involved iron levels liver matrix Mattson MELAS metabolism mice mito mitochon mitochondrial disease mitochondrial DNA mitochondrial dysfunction mitochondrial myopathy molecular molecules MPP+ MPTP mtDNA mtDNA depletion mtDNA mutations Natl Neupert Neurochem neurodegenerative Neurology neurons Neurosci oxidative damage oxidative stress Parkinson’s disease patients phenotype point mutations precursor preproteins presequences rats receptor replication respiratory chain role Schapira sequence skeletal muscle spastic striatal studies subunit syndrome synthesis tion tissue toxicity transcription transgenic translocation tRNA yeast