Mitochondrial Function and Dysfunction
Academic Press, Jan 10, 2003 - Medical - 559 pages
Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease.
* Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction
* Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases
* Includes outstanding list of contributing authors
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PRIMARY RESPIRATORY CHAIN DISORDERS
SECONDARY RESPIRATORY CHAIN DISORDERS
TOXININDUCED MITOCHONDRIAL DYSFUNCTION
MODELS OF MITOCHONDRIAL DISEASE
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abnormalities Acad activity Alzheimer’s disease apoptosis associated ataxia autosomal Beal binding Biochem Biol Biophys brain carnitine cellular Chem chondrial clinical coenzyme Q10 complex copper cybrid cytochrome oxidase cytosolic defect dehydrogenase DiMauro disorders domain dopamine drial electron encoded enzyme etal excitotoxic fatty acids ﬁbers ﬁbroblasts ﬁndings ﬁrst frataxin FRDA free radical Friedreich’s ataxia function Genet genome human Huntington’s disease identiﬁed impaired increased inhibition inner membrane involved iron levels liver Mattson MELAS metabolism mice mito mitochon mitochondrial disease mitochondrial DNA mitochondrial dysfunction mitochondrial membrane mitochondrial myopathy molecular MPP+ MPTP mtDNA mtDNA deletions mtDNA mutations Natl Neupert Neurochem neurodegenerative Neurology neurons Neurosci oxidative damage oxidative stress Parkinson’s disease patients phenotype point mutations precursor preproteins presequence rats receptor replication respiratory chain role Schapira sequence signiﬁcant skeletal muscle spastic speciﬁc striatal studies subunit syndrome synthesis tion tissue toxicity transcription transgenic translocation tRNA yeast