An Introduction to Chemical Pharmacology: Pharmacodynamics in Relation to Chemistry

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P. Blakiston's son & Company, 1921 - Pharmaceutical chemistry - 418 pages
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Page 79 - It is prepared by the action of iodine upon alcohol or acetone, in the presence of an alkali or an alkaline carbonate.
Page 233 - The optimum carbon-skeleton for sympathomimetic activity consists of a benzene ring with a side-chain of two carbon-atoms, the terminal one bearing the amino-group. Another optimum condition is the presence of two phenolic hydroxyls in the 3 : 4 position relative to the side-chain: when these are present, an alcoholic hydroxyl still further intensifies the activity. A phenolic hydroxyl in the 1 position does not increase the activity.
Page 211 - They define a glucophore as a group of atoms which has the power to form sweet compounds by uniting with a number of otherwise tasteless atoms or radicals.
Page 233 - We describe all such amines and their action as " sympathomimetic." (2) Approximation to adrenine in structure is, on the whole, attended with increasing intensity of sympathomimetic activity, and with increasing specificity of the action. (3) All the substances producing this action in characteristic manner are primary and secondary amines. The quarternary amines corresponding to the aromatic members of the series have an action closely similar to that of nicotine. (4) The optimum carbon-skeleton...
Page 212 - CC13 which also agrees with the general formula. The index (y) has the same significance as (x) but varies from one to two. The following atoms or radicals seem to act as auxoglucs, yielding with glucophores sweet compounds : (a) H, hydrogen. (6) The radicals, CnH2n+iO, of saturated hydrocarbons, containing from 1 to 3 carbon atoms. Example CH3CH2 — (c) The radicals CnH2n+iO of monohydric alcohols, n being equal to one or two. Example CH2OH — (d) The radicals CnH2n-iO
Page 218 - Boil 5 grm. of tea for half an hour with 400 cc of water; cool, and make up to 500 cc To 10 cc of the infusion (filtered if not clear) add' 25 cc of indigo-carmine solution and about 750 cc of water in a large porcelain basin.
Page 122 - ... with another gram of anhydrous sodium carbonate. Gradually raise the temperature to that of dull redness, and hold at this temperature until the whole is carbonized completely. This converts the iodide into sodium iodide. Cool and extract with hot distilled water. Filter and wash until the filtrate shows no test with silver nitrate (all the iodide has been dissolved) . Evaporate the filtrate and washings to 150 cc. on a water bath, and add an aqueous solution of KMnO4 (1:20) until the hot liquid...
Page 186 - H— C— OH H— C— OH I HO— C— H H— C— OH III. Emulsin Aesculin Amygdalin Androsin Arbutin Aucubin Benzyl-glucoside Coniferin Daphnin Dhurrin Gentiopicrin Glyceryl-glucoside synigrin Helicin Incaratrin Indican Lactose Melatin Methyl-d-galactoside 8. Methyl-d-glucoside 6. Oleuropein Picein Prunasin Prulaurasin C = O...
Page 122 - Dithymol-di-iodid, popularly known as aristol, is obtained by the condensation of two molecules of thymol and the introduction of two atoms of iodin into the phenolic groups of the thymol.
Page 406 - The sodium nitrite deteriorates upon standing and becomes unfit for use in the course of a few weeks. Esbach's Reagent.2 — Dissolve 10 grams of picric acid and 20 grams of citric acid in 1 liter of water. Fehling's Solution.

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