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ACPJCOD adverse outcome answer apply best evidence best external evidence Chapter clinical decision analysis clinical practice clinical problem clinical questions clinically important clinicians Cochrane Collaboration confidence interval consider critical appraisal database decide decision analysis develop diagnostic test disease drug educational prescription effects efficacy evaluation evidence resource Evidence-Based Medicine example ferritin follow-up Further reading guideline guides Guyatt harm Helicobacter pylori identify individual clinical expertise individual patient insulin interferon interventions JAMA journal club learners learning likelihood ratios Medicine Working Group MEDLINE multiple sclerosis myocardial infarction nomogram overview Oxford post-test probabilities practicing EBM pretest probabilities prognosis randomized trials regimen relative risk relative risk reduction relevant renal failure risk reduction Sackett search strategy Section sensitivity session specific summarized systematic review Table target disorder teach EBM test result therapeutic therapy treat treatment ulcerative colitis valid workshops