NanoCellBiology of Secretion: Imaging Its Cellular and Molecular Underpinnings
Understanding live cells at the single molecule level is the most important and single major challenge facing biology and medicine today. Over the past 15 years, there has been a renewed understanding of living cells at the molecular level. Atomic Force Microscopy, Laser Force Microscopy, single secretory vesicle patch clamp studies, highresolution electron microscopy, and x-ray diffraction, are some of the tools now being used to unravel the intricacies of a living cell at the molecular level. Opening with an explanation of Materials and Methods, NanoCellBiology then moves through discussions of porosome discovery, calcium and SNARE-induced fusion, and vesicle swelling before winding up in a final chapter of conclusions and future studies. Succinctly packaged as SpringerBrief, this book is a must for those studying or conducting research in cell biology, biochemistry or nanobiology/nanotechnology. This book will be invaluable to faculty & graduate students involved in Nano Courses; Cell Biology Courses; Biophysics Courses; and Biochemistry Courses as well as practicing Cell Biologists, Biochemists and BioPhysicists.
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a-amylase adrenergic receptors AFM micrograph alprenolol amylase antibody apical plasma membrane b2AR Bhanu Jena Fig bilayer chamber Ca2+ calcium capacitance Cell Biol Int Cell Mol cell plasma membrane cell secretion Cho S-J Cho WJ cholesterol cup-shaped dynamics earlier publication exocrine pancreas exocytosis expulsion following exposure following stimulation fuse fusion pore glyburide imaged immunoblot immunoblot analysis immunoisolated increase inhibitor interact intravesicular contents isolated ZGs Jena BP Jeremic light scattering liposomes live cells live pancreatic acinar mastoparan membrane-associated microscopy molecular myosin nanometer neuronal neurotransmitters nm in diameter NSF–ATP nystatin opposing bilayers opposing membranes pancreatic acinar cells plasma membrane presence protein red arrowhead release secretory portal secretory stimulus secretory vesicle swelling secretory vesicles SNARE complex SNARE proteins SNARE ring complex spectroscopy studies demonstrate synaptic vesicle swelling synaptic vesicles syntaxin t-/v-SNARE complex t-/v-SNARE ring complex t-SNAREs t-SNAREs and v-SNARE trans compartment v-SNARE vesicles v-SNARE-reconstituted vesicles vesicular contents ZG swelling zymogen