Parkinson's Disease: Molecular and Therapeutic Insights From Model Systems
Richard Nass, Serge Przedborski
Elsevier, Apr 28, 2011 - Psychology - 686 pages
Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Acad Sci USA aggregation alpha-synuclein animal models Ann Neurol autophagy Biol Chem Brain Res Caenorhabditis elegans cell death cellular chaperone chronic clinical complex cultures Dawson degeneration dementia disorders dopamine neurons dopaminergic neurons Drosophila drug dysfunction effects elegans exposure expression factors fibrils function gene genetic genome human identified increased induced inhibition inhibitors interactions kinase Langston lesions levodopa Lewy bodies lipid loss LRRK2 mechanisms membrane mesencephalic microglia midbrain mitochondrial model of Parkinson’s models of PD molecular monkeys motor mouse model MPTP mutations Natl Acad Sci Neurochem neurodegeneration neuroprotective Neurosci neurotoxicity nigrostriatal o-synuclein overexpression oxidative stress paraquat parkin Parkinson’s disease parkinsonian pathogenesis pathology pathway patients PC12 cells phenotype phosphorylation PINK1 Proc Natl Acad proteasome protein Przedborski receptor role rotenone screen striatal striatum structure studies substantia nigra synuclein target therapeutic tion toxicity toxin transgenic transgenic mice ubiquitin vitro vivo wild-type yeast zebrafish