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Very dense and erudite. Plan on spending a lot of time to read it all. It took me a year because I had to read and re-read each sentence and then the whole paragraph. But it was worth it.
In my naive and unscholarly opinion, the most important work on epistemology in the 20th Century. I wish he were around now to comment on the cyber-age and the way knowledge is developing (or deteriorating) a a result of about 2 billion of us being able to communicate instantaneously with everyone else (theoretically, that is)
The other great 20th Century epistemologist was Yogi Bera who said that "in theory, there is no difference between theory and practice. In practice, there is." (http://www.brainyquote.com/quotes/quotes/y/yogiberra141506.html)
Review: Mind and Nature: A Necessary UnityUser Review - Nick Urban - Goodreads
A great scientist's introduction to epistemology. Read full review