Liquid Chromatography: Mass Spectrometry, Second Edition

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CRC Press, Sep 1, 1998 - Science - 648 pages
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This volume comprehensively relates developments, principles, and applications of combined liquid chromatography-mass spectrometry and other techniques such as capillary electrophoresis and supercritical fluid chromatography combined with mass spectrometry. It covers historical developments, currently important interfaces and technologies, and LC-MS applications in environmental analysis, pharmaceuticals and bioanalysis, and additional fields. It offers in-depth coverage of interfaces and technologies currently important in the laboratory, especially electrospray and APCI, contains an expanded applications section, and provides over 2200 references, tables, equations, and drawings.
 

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Contents

Introduction to Liquid Chromatography
3
Introduction to Mass Spectrometry
31
General Instrumental Considerations in LCMS Interfacing
71
Interface Technology
97
History of LCMS
99
ParticleBeam Interface
135
ContinuousFlow FastAtom Bombardment
165
Thermospray Interface
187
Related Techniques
286
AtmosphericPressure Chemical Ionization Interfaces
337
Recent Developments in LCMS Interfacing
347
Environmental Applications of LCMS
359
Pharmaceutical Applications of LCMS
405
Natural Products and Endogenous Compounds
465
Biochemical Applications of LCMS
501
Miscellaneous Applications of LCMS
539

Nebulization Ionization in LCMS
235
Electrospray Interfacing
285

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