S-adenosylmethionine-dependent Methyltransferases: Structures and Functions

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World Scientific, 1999 - Science - 400 pages
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This invaluable volume, written by an international group of scientists, presents an overview of the AdoMet-dependent methyltransferases, with special emphasis on structure-function relationships.

S-adenosyl-L-methionine (AdoMet) is the second most commonly used enzyme cofactor after ATP. The AdoMet-dependent methyltransferases act on a wide variety of target molecules, including DNA, RNA, protein, polysaccharides, lipids and a range of small molecules.

The well-conserved architecture of these enzymes, and the implications of this conservation for their evolutionary history, are major themes of this book. The thirteen chapters describe in detail the structures, enzyme kinetics and biological roles of the AdoMet-dependent methyltransferases from a wide range of cell types: plant, animal, bacterial and archaeal.

 

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Contents

Structure and Evolution of AdoMetDependent
1
A common architecture for AdoMetdependent MTases
8
A relationship between the AdoMetdependent MTases and the
20
Does the structural conservation among AdoMetdependent MTases
27
References
32
The Black Sheep of the Family AdoMetDependent
39
Precorrin MTase CbiF
46
Acknowledgements
52
References
173
tRNA Methyltransferases
185
References
194
MTases involved in rRNA processing and maturation
201
Structureguided amino acid sequence comparisons among
214
Nucleoside Methylation in Eukaryotic mRNA
227
Characterization and purification of HeLa mRNA N6mA MTase
235
Conclusion
247

Subcellular localization of COMTase proteins
58
References
80
Glycine WMethyltransferase A Tetrameric Enzyme
93
Crystal structure of rat GNMTase
101
Comparison to the structure and function of AdoHcy hydrolasc
111
Future work
117
A Protein Carboxyl Methyltransferase that
123
Substrate specificity of the MTase
131
References
140
Protein Methyltransferases Involved in Signal
149
Prenylcysteine MTases
160
Phosphoprotein phosphatase 2A MTases
166
VP39 An mRNA CapSpecific
255
Interaction between VP39s two functions
277
Bacterial DNA Methyltransferases
283
Classification of DNA MTases
295
Chemical reactions of DNA MTases
306
Acknowledgements
321
Eukaryotic DNA Methyltransferases
341
Dnmtl family MTases
349
Dnmt2 family MTases
357
Mechanisms of DNA Demethylation in Vertebrates
373
Appendix I
393
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