Mechanisms of Cancer Metastasis: Potential Therapeutic ImplicationsKenneth V. Honn, William E. Powers, Bonnie F. Sloane The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej udices of the editors. |
Contents
PRESENT STATUS AND FUTURE PROSPECTS | 15 |
A CRITICAL OVERVIEW OF THE METASTATIC | 23 |
EXPERIMENTAL MODELS FOR STUDYING | 41 |
Copyright | |
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Other editions - View all
Mechanisms of Cancer Metastasis: Potential Therapeutic Implications Kenneth V. Honn,William E. Powers,Bonnie F. Sloane No preview available - 2011 |
Mechanisms of Cancer Metastasis Kenneth V Honn,William E Powers,Bonnie F Sloane No preview available - 1985 |
Common terms and phrases
agents animals anticoagulant antigens assay B16 cells basal lamina basement membrane Biochem Biol blood breast tumors cancer cells cancer procoagulant Cancer Res carcinoma cathepsin cathepsin B activity cell lines cell populations cell surface cellular chemotactic clones coagulation collagenase colonization components correlation culture cytotoxic degradation drug effect endothelial cells enzymes epithelial experimental extracellular extracellular matrix fibrin fibronectin Fidler IJ glycoproteins heterogeneity Honn KV host human breast human tumor implantation incubated inhibition inhibitors injected interactions invasion and metastasis laminin leukocytes Liotta liposomes liver lung macrophages malignant cells mammary mammary tumor matrix mechanism metastasis metastatic cells metastatic potential monoclonal antibodies mouse murine Natl neoplastic Nicolson NK cells normal nude mice organ patients PGI2 phenotypic plasmin plasminogen plasminogen activator platelet platelet aggregation procoagulant activity prostaglandin proteinase proteolytic released resistance response role RSVCEF sarcoma studies subpopulations therapeutic therapy tissue treatment tumor invasion type IV collagen variants vascular vitro vivo warfarin