Mechanisms of Cancer Metastasis: Potential Therapeutic Implications
Kenneth V. Honn, William E. Powers, Bonnie F. Sloane
Springer, 1986 - Medical - 428 pages
The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej udices of the editors.
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PRESENT STATUS AND FUTURE PROSPECTS
A CRITICAL OVERVIEW OF THE METASTATIC
EXPERIMENTAL MODELS FOR STUDYING
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agents animals anticoagulant antigens B16 melanoma basal lamina basement membrane Biochem Biol blood breast tumors cancer cells Cancer Res carcinoma catheps cathepsin cathepsin B activity cell lines cell populations cell surface cellular chemotactic clones coagulation collagenase colon components correlation culture cytotoxic degradation drug effect endothelial cells enzymes epithelial experimental extracellular extracellular matrix fibrin fibronectin Fidler IJ Figure glycoproteins growth factors heterogeneity HME-Ags Honn KV host human breast human tumor implantation incubated inhibition inhibitors injected interactions invasion and metastasis laminin leukocytes Liotta liver macrophages malignant cells mammary mammary tumor matrix mechanism melanoma cells meta static metastasis metastatic potential monoclonal antibodies mouse murine Natl neoplastic NK cells normal nude mice organ patients PGI2 phenotypic plasmin plasminogen plasminogen activator primary tumor procoagulant protein proteinase proteolytic pulmonary released resistance response role RSVCEF sarcoma studies subpopulations therapy tissue treatment tumor cells tumor invasion type IV collagen variants vascular vitro vivo warfarin