DHEA in Human Health and Aging

Front Cover
Ronald Ross Watson
CRC Press, Jul 22, 2011 - Medical - 472 pages

Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study.

With contributions from a cadre of international experts, this volume examines:

  • The biology of DHEA relevant to health in humans
  • Areas of potential clinical importance concerning low levels of DHEA related to age or physiological change
  • Prevention as well as treatment of various human disease states by changing DHEA levels
  • The use of DHEA levels in predicting the risk of disease
  • The role of DHEA in diabetes, fitness, infectious disease, cancer, AIDS, bone health, cardiovascular diseases, autism, and mental health
  • Animal models and their relation to studies done on humans
  • The effects of loss of adrenal gland function, the subsequent reduction in DHEA production, and its replacement as therapy
  • Adverse effects in DHEA-supplemented women
  • Mechanisms of action of DHEA in prostate and ovarian health, vascular modification, stress, memory, aggression, and Alzheimer’s disease

Covering a wide range of topics, the book is compiled from contributions of experts who have each studied some aspect of DHEA and human or animal health or disease. Every chapter is self-contained, allowing for focused study on individual topics. Edited by one of the leading experts in the field of nutrition, the book presents a compelling view of the state of the science in DHEA.

 

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Contents

DHEA versus Androstenediol in MiddleAged Women
3
DHEA as a Putative Replacement Therapy in the Elderly
9
Dehydroepiandrosterone Its Metabolites and Resistance to Infections
37
DHEA and Glucose Metabolism in Skeletal Muscle
51
DHEA and Dyskinesias
59
Dehydroepiandrosterone Its Effects on Cell Proliferation and Cancer
69
Dehydroepiandrosterone and Energy Metabolism
87
Dehydroepiandrosterone in Human Immunodeficiency Virus Infection Monitoring and Therapy
103
DHEA Androgen Receptors and Their Potential Role in Breast Cancer
253
DHEAS and Periodontal Status in Older Japanese
263
DHEA Levels and Increased Risk of Atherosclerosis and Cardiovascular Disease
277
DHEAS and Related Factors in Autism
287
DHEA Antiviral Properties in Cell Cultures and Animal Models
301
Adipose Tissue as a Target for Dehydroepiandrosterone and Its Sulfate
313
Dehydroepiandrosterone and Cell Differentiation
331
DHEA Oxidative Stress and Akt
335

Dehydroepiandrosterone Replacement and Bone Mineral Density
113
DHEA and Vascular Health and Functions
123
DHEA and IschemiaReperfusion Injury Prevention
141
DHEA and Cancer Risk or Prevention?
153
Dehydroepiandrosterone in Intracellular Infectious Diseases and Related Pathogens
173
Dehydroepiandrosterone Sulfate and Vascular Remodeling
185
DHEA in Human Immunodeficiency Virus Infection Prognostic and Therapeutic Aspects
195
DHEA and Its Metabolites and Analogs A Role in Immune Modulation and Arthritis Treatment?
207
Asthma and DHEA
219
DHEA in Allergy Asthma and UrticariaAngioedema
227
The Role of DHEA in Mental Disorders
239
Evidence for a Cellular DHEA Receptor
341
Dehydroepiandrosterone and Testosterone Effects on Erectile Function
351
DHEA Metabolism Supplementation and Decline with Age Role on Prostate Health
363
DHEA and Vascular Function
375
DHEAS and Coping Capability
389
DHEA and Memory
399
DHEA and Aggression
415
DHEA and Alzheimers Disease
433
Back Cover
447
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About the author (2011)

Ronald R. Watson, PhD, is a member of several national and international nutrition, immunology, cancer, and alcoholism research societies. For 30 years he was funded by Wallace Research Foundation to study dietary supplements in health promotion. Dr. Watson has edited more than 35 books on nutrition, dietary supplements, and over-the-counter agents, and 53 other scientific books. He has published more than 500 research and review articles. He has done DHEA research in mice for 20 years and has just completed an NIH grant studying DHEA in cardiac function in mice.

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