Analysis of Human Genetic Linkage"For the last decade this book has been the unrivaled standard text on human genetic linkage analysis." -- Biometrics"One of the best books that cover the theory behind linkage analysis. Scientists with an interest in genetic linkage analysis should definitely consider allocating space on their bookshelves for this book." -- Biotech Software and Internet Report"A valuable resource. It is the most accessible work on the subject, and should be in the collection of everyone interested in mapping human genes." -- Doody's Book Review Service |
Contents
Basic Genetics and Cytogenetics | 1 |
Genes and Genetic Polymorphisms | 23 |
Aspects of Statistical Inference | 39 |
Copyright | |
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Common terms and phrases
affected approximately assumed asymptotic autosomal calculated chromosome conditional probability confidence interval consider corresponding crossovers disease allele disease gene distribution ELOD equal equation example expected information expected lod score family types gametes gene frequencies gene mapping genetic linkage genome genotypes given H₁ Haldane haplotypes heterogeneity heterozygosity heterozygous homozygous incomplete penetrance individuals informative for linkage interference known Kosambi large number likelihood ratio linkage analysis linkage disequilibrium LINKAGE programs linked loci locus orders log likelihood male map distance map function map length marker loci maximum lod score meioses method misclassification multipoint nonrecombinant obtained offspring phenotype p-value p₁ pairs parents pedigree percent phase phase-known double backcross phenotype polymorphic prior probability probability of linkage probability of occurrence proband problem proportion recombination events recombination fraction recombination rates risk significance level statistical support interval three loci tion traits true recombination fraction two-point X-linked x₁ Zmax Өвс