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acute agents androgen aplastic anemia ataxia ataxia-telangiectasia blood Bloom's syndrome bone marrow cancer Cancer Res carcinogenesis carcinogens carcinoma cell lines cellular chemical chro chromo chromosome aberrations chromosome breakage chromosome changes chromosome instability chromosome-breakage syndromes Clin clinical clonal clones Cockayne's syndrome complementation groups cultures cytogenetic defect deficiency diagnosis disease disorders DNA damage DNA repair DNA synthesis effect enzyme excision exposure Fanconi's anemia fibroblasts gene genome German growth human cancers human cells hypersensitivity immunodeficiency increased induced lesions leukemia leukemic lymphocytes lymphoid lymphoma malignant mitomycin molecular mosome mutagens Mutat NatL Acad neoplasia neoplasms neurological abnormalities normal cells observed occur oncogenes persons population Proc radiation reported SCE frequency sensitivity sister chromatid exchanges skin somatic specific spontaneous studies T-cell telangiectasia tients tion tissue transformation translocation tumors types viral virus vitro Werner's syndrome xeroderma pigmentosum xeroderma pigmentosum cells XP cells XP patients