Bile acids and the hepatobiliary system: from basic science to clinical practice : proceedings of the 68th Falk Symposium held in Basel, Switzerland, October 12-14, 1992
Kluwer Academic Publishers, 1993 - Medical - 328 pages
Bile acids have recently found application in the treatment of hepatobiliary diseases. Chenodeoxycholic acid and ursodeoxycholic acid have proved to be effective agents for the dissolution of cholesterol gallstones, and ursodeoxycholic acid has been shown to have beneficial effects in patients with chronic cholestatic liver disease such as primary biliary cirrhosis or primary sclerosing cholangitis. The question of the long-term benefit for the patient remains open and the mechanism of action is still unclear. As a consequence, much basic and clinical research is being conducted on bile acid therapy. The XIIth International Bile Acid Meeting brought together researchers and clinicians from around the world, and was dedicated to basic and clinical aspects of the use of bile acids in the therapy of hepatobiliary disease.
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Invitro and invivo studies of hormonal regulation
Enzymatic conversion of 27hydroxycholesterol to 7a
29 other sections not shown
27-hydroxycholesterol acid conjugates ATP-dependent transport bile acid bile acid synthesis bile acid transport bile flow bile salt biliary lipid bilirubin Biochem Biol Chem biosynthesis Ca2+ canalicular canalicular membrane CDCA cDNA cells chenodeoxycholic acid cholate cholehepatic cholestasis cholesterol 7a cholesterol 7a-hydroxylase activity cholesterol 7a-hydroxylase mRNA cholestyramine cholic acid cholyltaurine chronic Clin Invest clinical cloning colchicine concentrations culture cyclosporin decrease dexamethasone drug effect of ursodeoxycholic enzyme excretion Gastroenterology Gerok glucuronide hepatic hepatocytes Hepatology human liver hydrophobic hydrophobic bile hydroxylase imol/l increase incubated induced inhibition lipid Lipid Res liver function membrane vesicles metabolism micelles microsomes mitochondrial mRNA mRNA levels organic anions patients Paumgartner G perfusion Physiol placebo plasma membrane Poupon primary biliary cirrhosis primary sclerosing cholangitis protein rat hepatocytes rat liver receptor secretion serum bilirubin sterol Stiehl substrates taurocholic acid transport system treatment TUDCA UDCA unconjugated uptake ursodeoxycholic acid