Bile Acids and the Hepatobiliary System: From Basic Science to Clinical PracticeG. Paumgartner, A. Stiehl, W. Gerok Bile acids have recently found application in the treatment of hepatobiliary diseases. Chenodeoxycholic acid and ursodeoxycholic acid have proved to be effective agents for the dissolution of cholesterol gallstones, and ursodeoxycholic acid has been shown to have beneficial effects in patients with chronic cholestatic liver disease such as primary biliary cirrhosis or primary sclerosing cholangitis. The question of the long-term benefit for the patient remains open and the mechanism of action is still unclear. As a consequence, much basic and clinical research is being conducted on bile acid therapy. The XIIth International Bile Acid Meeting brought together researchers and clinicians from around the world, and was dedicated to basic and clinical aspects of the use of bile acids in the therapy of hepatobiliary disease. |
Contents
Invitro regulation of hepatic 3chydroxysteroid | 5 |
Invitro and invivo studies of hormonal regulation | 33 |
AXELSON MD | 46 |
Copyright | |
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activity addition analysis anion appears ATP-dependent bile acid bile acid synthesis bile flow bile salt biliary bilirubin binding Biochem Biol Chem Ca2+ canalicular canalicular membrane CDCA cDNA cells changes cholestasis cholesterol 7a-hydroxylase chromatography chronic clinical cloning compared concentrations conjugates containing cultured decrease demonstrated determined drug effect enzyme excretion experiments expression fraction function Gastroenterology gene hepatic Hepatology human hydrophobic improvement increase incubation indicating induced inhibition isolated levels lipid liver disease mean measured mechanism membrane method microsomes mitochondrial mRNA normal observed obtained organic patients perfusion presence primary primary biliary cirrhosis protein rat hepatocytes rat liver recently regulation reported respectively secretion serum showed shown specific sterol structure substrates suggest Table taurocholate therapy transport system treatment UDCA umol/l uptake ursodeoxycholic acid values vesicles