Neurodevelopmental Mechanisms in Psychopathology
This volume represents a burgeoning perspective on the origins of psychopathology, one that focuses on the development of the human central nervous system. The contemporary neurodevelopmental perspective assumes that mental disorders result from etiologic factors that alter the normal course of brain development. Defined here in its broadest sense, neurodevelopment is a process that begins at conception and extends throughout the life span. We now know that it is a complex process, and that its course can be altered by a host of factors, ranging from inherited genetic liabilities to psychosocial stressors. This book features the very best thinking in the converging fields of developmental neuroscience and developmental psychopathology. The developmental window represented is broad, extending from the prenatal period through adulthood, and the authors cover a broad range of etiologic factors and a spectrum of clinical disorders. Moreover, the contributors did not hesitate to use the opportunity to hypothesize about underlying mechanisms and to speculate on research directions.
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abnormalities abuse activity ADHD adolescence adult affective disorders aggression alterations American Journal amygdala Archives assessment associated autism behavior Biological Psychiatry cell child childhood Cicchetti clinical cocaine cognitive controls correlates cortical cortisol cortisol levels cytokines deficits depressed mothers depression developmental psychopathology diagnostic differences disruptive dopamine dopaminergic drug early effects emotional environment environmental influences episodes fetal findings function genetic gestation hippocampal hormone HPA axis human hypoxia immune impairment increased individuals infants interactions investigation Journal of Psychiatry linkage maltreated children maternal mechanisms mediate Mednick mental neonatal neural neurobehavioral neurobiological neurodevelopmental Neurology neurons Neuroscience neurotransmitter normal obstetric offspring onset outcome parenting patients percent personality disorder postnatal potential prefrontal cortex pregnancy prenatal exposure prenatal stress preterm primate psychological rats receptor response rhesus monkeys risk factors role sample schizophrenia schizotypal personality disorder serotonin social specific stressors structures studies suggest symptoms teratogenic teratology traits twin twin studies variables vulnerability
Page 483 - Collier, DA, Stober, G., Li, T., Heils, A., Catalano, M., Di Bella, D., Arranz, MJ, Murray, RM, Vallada, HP, Bengel, D., Muller, CR, Roberts, GW, Smeraldi, E., Kirov, G., Sham, P., & Lesch, KP (1996). A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in