Bile Acids and Cholestasis
Springer, Jun 30, 1999 - Medical - 291 pages
Since the last International Bile Acid Meeting in Freiburg in 1996, considerable progress has been made in several areas of bile acid research. The different pathways of bile acid synthesis and their regulation have been further characterized. The molecular mechanisms for biliary secretion of bile acids have been elucidated and genetic defects of bile acid transport have been defined. Injurious as well as protective effects of different bile acids on the liver have been further studied. Finally, the beneficial effects of ursodeoxycholic acid in cholestatic liver diseases have been substantiated and the potential mechanisms of action have been explored. This book, the proceedings of the Falk Symposium No. 108 (XV International Bile Acid Meeting), held in Titisee, Germany, October 12-13, 1998, is dedicated to both basic and clinical aspects of bile acid research with a focus on bile acids and cholestasis.
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Taurohyodeoxycholic acid prevents taurochenodeoxycholic
The regulation of different bile acid biosynthetic pathways
Signal transduction pathways regulating cholesterol
24 other sections not shown
activity apoptosis ASBT ATP-dependent basolateral bile acid synthesis bile acid transport bile duct bile salt bile salt export bile salt transport binding Biochem Biol Chem Boyer JL Bsep canalicular canalicular bile salt canalicular membrane caspase cells chenodeoxycholic acid cholangiocytes cholate cholestasis cholestatic cholestatic liver disease cholesterol cholesterol 7a-hydroxylase cholic acid Clin Invest cloning concentrations cotransporter down-regulation excretion expression Falk Symposium familial intrahepatic cholestasis fibrosis Figure function Gastroenterology glucagon Hagenbuch hepatic hepatocellular hepatocytes Hepatology human ileal bile acid inhibition intestinal Lipid Res mdr2 Meier PJ membrane vesicles mice molecular mRNA mRNA levels MRP2 mutations Nat/bile norcholansulphonate Ntcp organic anion transporter P-glycoprotein patients PFIC photoaffinity labelling Physiol primary biliary cirrhosis progressive familial intrahepatic rat hepatocytes rat liver receptor regulation salt export pump secretion sequence serum sodium-dependent bile acid Spgp sterol sterol 12a-hydroxylase Stieger studies substrate taurocholate transcription factors transport system TUDCA UDCA umol/L uptake ursodeoxycholic acid Vlahcevic ZR