Analysis of Human Genetic Linkage
The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book.
New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
What people are saying - Write a review
Introduction and Basic Genetic Principles
Genetic Loci and Genetic Polymorphisms
Aspects of Statistical Inference
Basics of Linkage Analysis
The Informativeness of Family Data
Multipoint Linkage Analysis
Linkage Analysis with Mendelian Disease Loci
Solutions to Study Problems
Numerical and Computerized Methods
Variability of the Recombination Fraction