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acute administration allergic reactions anaphylactic reactions anti Antib antibiotic therapy antibiotic-resistant Antibiotics Annual aplastic anaemia appeared associates aureomycin bacitracin bacteria biotics Brit broad-spectrum antibiotics Candida albicans caused cent chloramphenicol chloramphenicol therapy chlortetracycline Clin clinical complications compounds connexion contact dermatitis cycloserine daily day of treatment deafness described developed diarrhoea disturbances dose drug effects enterocolitis erythema erythromycin fatal fever frequently fumagillin grammes grammes of streptomycin hospital hypersensitivity increase infections irritation isolated itching kidney damage Lancet lesions liver maculopapular manifestations medication mentioned mucous membranes mycin nausea neomycin novobiocin nurses observed occur oedema ototoxic oxytetracycline parenteral patient received penicillin therapy penicillin treatment polymyxin procaine penicillin purpura reaction to penicillin reported resistant strains sensitivity serum severe showed side-effects skin reactions staphylococci strepto streptoduocin streptomycin streptomycin and dihydrostreptomycin streptomycin therapy substance symptoms Syph terramycin tetracycline therapeutic tion toxic treated tuberculosis units of penicillin untoward urticaria vestibular vomiting weeks Welch