Modelling Methodology for Physiology and Medicine

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Ewart Carson, Claudio Cobelli
Elsevier, Dec 31, 2000 - Technology & Engineering - 421 pages
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Modelling Methodology for Physiology and Medicine offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modelling methodology that is widely applicable to physiology and medicine. The book opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration.
  • Builds upon and enhances the readers existing knowledge of modelling methodology and practice
  • Editors are internationally renowned leaders in their respective fields
 

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Contents

Chapter 2 Control in Physiology And Medicine
15
Chapter 3 Deconvolution
45
Chapter 4 A priori Identifiability of Physiological Parametric Models
77
Chapter 5 Parameter Estimation
107
Chapter 6 Tracer Experiment Design for Metabolic Fluxes Estimation in Steady and Nonsteady State
153
Chapter 7 Physiological Modelling of Positron Emission Tomography Images
179
Chapter 8 Identification and Physiological Interpretation of Aortic Impedance in Modelling
213
Chapter 9 Mathematical Modelling of Pulmonary Gas Exchange
253
Chapter 10 Mathematical Models of Respiratory Mechanics
279
Chapter 11 Insulin Modelling
305
Chapter 12 Glucose Modeling
337
Chapter 13 BloodTissue Exchange Modelling
373
Index
403
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Page 398 - Crone, C. , The permeability of capillaries in various organs as determined by use of the 'indicator diffusion
Page 398 - Tätigkeit der Lungen bei der respiratorischen Gasaufnahme und ihr Verhalten zu der durch die Alveolarwand stattfindenden Gasdiffusion.
Page 398 - TransCapillary Exchange of Water and of Other Substances in Certain Organs of the Dog.

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About the author (2000)

Ewart Carson is Emeritus Professor of Systems Science in the School of Mathematics, Computer Science and Engineering at City, University of London. Educated at the University of St Andrews in Scotland and City University London, he holds a PhD in Systems Science and a DSc in Measurement and Information in Medicine. He holds Honorary Membership of the Royal College of Physicians (London) , a Life Fellowship of the IEEE, Fellowships of the International Academy of Medical and Biological Engineering and the American Institute of Medical and Biological Engineers, and is a Foundation Fellow of the European Alliance for Medical and Biological Engineering and Science Publications include 13 authored and edited books and more than 300 journal papers and chapters. Areas of research interest and expertise include: modelling in physiology and medicine; modelling methodology for health resource management; clinical decision support systems; evaluation methodologies with particular application in telemedicine; and integrated policy modelling for ICT enhanced public healthcare. As a systems scientist, all this research is undertaken within a clear systemic framework.

Claudio Cobelli received a Doctoral degree (Laurea) in Electrical Engineering in 1970 from the University of Padova, Padova, Italy. From 1970 to 1980, he was a Research Fellow of the Institute of System Science and Biomedical Engineering, National Research Council, Padova, Italy. From 1973 to 1975 and 1975 to 1981, he was Associate Professor of Biological Systems at the University of Florence and Associate Professor of Biomedical Engineering at the University of Padova, respectively. In 1981, he becomes Full Professor of Biomedical Engineering at University of Padova. From 2000 to 2009, he has been Chairman of the Graduate Program in Biomedical Engineering. From 2000 to 2011, he has been Chairman of the Ph.D. Program in Bioengineering at the University of Padova. His main research activity is in the field of modeling and identification of physiological systems, especially metabolic systems. His research is currently supported by NIH, JDRF and European Comunity. He has published 450 papers in internationally refereed journals, co-author of 8 books and holds 11 patents. He is currently Associate Editor of IEEE Transaction on Biomedical Engineering and Journal of Diabetes Science & Technology. He is on the Editorial Board of Diabetes and Diabetes Technology &Therapeutics. Dr.Cobelli has been Chairman (1999-2004) of the Italian Biomedical Engineering Group, Chairman (1990-1993 & 1993-1996) of IFAC TC on Modeling and Control of Biomedical Systems and member of the IEEE EMBS AdCom Member (2008-2009). He has been a member of the Gruppo di Esperti della Valutazione (GEV), Area 09, of the Agenzia Nazionale per la Valutazione del Sistema Universitario e della Ricerca (ANVUR) for the period 2011-2013. He is President of the Organo di Indirizzo of the Azienda Ospedaliera Universita' di Trieste In 2010 he received the Diabetes Technology Artificial Pancreas Research Award. He is Fellow of IEEE, BMES and EAMBES.

Joseph Bronzino is one of the most renowned biomedical engineers in the world. He is a former president of the IEEE Engineering in Medicine and Biology, and well-known educator. He is editor-in-chief of the Biomedical Engineering Handbook from CRC Press, and is currently editor of the Academic Press Series in Biomedical Engineering. He is the Vernon Roosa Professor of Applied Science at Trinity College in Hartford, Connecticut.