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acetylcholine acid ACTH action activity adrenaline adrenergic agents agonist alkaloids amines anaesthesia anaesthetic analgesic animals antagonists antipsychotic Arch avoidance behaviour Bacq barbiturates benzodiazepines binding sites biochemical Bohus Bowman brain Cannabis Cannon Carlsson catecholamines chemical transmission chlorpromazine cholinoceptors clinical cocaine compounds curare Dale decamethonium demonstrated depolarizing depression derivatives discovery dopa dopamine doses effects endogenous endorphins endplate enzyme eserine ether experimental experiments Feldberg fibres function GABA Gaddum Haefely haloperidol imipramine inhibition inhibitors injection iproniazid isolated laboratory Loewi mechanism mediator medicine membrane metabolism molecule monoamines muscle nalorphine neurohypophyseal hormones neuroleptics neuromuscular blocking drugs neuronal nitrous oxide noradrenaline opium patients Paton and Zaimis peptides phar Pharmacol Pharmacology Physiol physiological pituitary poppy potential produced psychoactive rats receptor release reserpine response Sourkes specific structure studies substance synthesis technique theory therapeutic tion treatment tricyclic antidepressants tubocurarine vasopressin Wied Zeller