Biocatalysis in the Pharmaceutical and Biotechnology IndustriesRamesh N. Patel Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemic |
Contents
| 1 | |
| 27 | |
A Decade of Biocatalysis at Glaxo Wellcome | 53 |
Biocatalysis for Synthesis for Chiral Pharmaceutical Intermediates | 103 |
Directed Evolution of Lipases and Esterases for Organic Synthesis | 159 |
FlavinContaining Oxidative Biocatalysts | 181 |
Preparation of Chiral Pharmaceuticals through Enzymatic Acylation of Alcohols and Amines | 203 |
Dynamic Kinetic Resolution and Asymmetric Transformations by EnzymeMetal Combinations | 249 |
Microbial and Enzymatic Processes for the Production of Chiral Compounds | 529 |
Discovery of Arylmalonate Decarboxylase and Conversion of the Function by Rational Design | 547 |
Chemoenzymatic Preparation of Enantiopure Building Blocks of Synthetic Utility | 563 |
Stereoselective Modifications of Polyhydroxylated Steroids | 591 |
Recent Developments in Enzymatic Acyloin Condensations | 605 |
Synthesis of Chiral Alcohols with Carbonyl Reductase Library and Robust NADPH Regenerating System | 623 |
Comparative Analysis of Chemical and Biocatalytic Syntheses of Drug Intermediates | 645 |
Industrial Processes Using Lyases for CC CN and CO Bond Formation | 661 |
Biotransformation of Natural or Synthetic Compounds for the Generation of Molecular Diversity | 273 |
Applications of Aromatic Hydrocarbon Dioxygenases | 299 |
A Genomic Approach to Investigating Bakers Yeast Reductions | 333 |
Immobilization of Enzymes as CrossLinked Enzyme Aggregates A Simple Method for Improving Performance | 351 |
Biotechnological Applications of Aldolases | 363 |
Enzymatic Synthesis of Modified Nucleosides | 401 |
Biocatalytic Reduction of Carboxylic Acids Mechanism and Applications | 425 |
Dehalogenases in Biodegradation and Biocatalysis | 441 |
Enzymatic Synthesis of Sugar Esters and Oligosaccharides from Renewable Resources | 463 |
Efficient Methods and Instrumentation for Engineering Custom Enzymes | 489 |
Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemoenzymatic Synthesis and Transformation of Antiviral Agents Structurally Relate... | 501 |
State of the Art and Applications in Stereoselective Synthesis of Chiral Cyanohydrins | 677 |
Chiral Switches Problems Strategies Opportunities and Experiences | 699 |
Enzyme Evolution for Chemical Process Applications | 717 |
Biocatalytic Routes to Nonracemic Chiral Amines | 743 |
Enantioselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols | 757 |
Enzyme Catalysis in Nonaqueous Media Past Present and Future | 791 |
Biocatalytic Concepts for the Synthesis of Optically Active Amines | 829 |
Color Plates | 849 |
Back Cover | 857 |
Other editions - View all
Biocatalysis in the Pharmaceutical and Biotechnology Industries Ramesh N. Patel No preview available - 2007 |
Biocatalysis in the Pharmaceutical and Biotechnology Industries Ramesh N. Patel No preview available - 1920 |
Biocatalysis in the Pharmaceutical and Biotechnology Industries Ramesh N. Patel No preview available - 2006 |
Common terms and phrases
acetate acylation adenosine alcohol aldehydes aldolase amines amino acid Appl applications aromatic asymmetric biocatalysts Biochem Bioeng Biol Biotechnol biotransformation Candida Candida antarctica carboxylic acids Catal catalyst catalyzed Chem chemical chemoenzymatic chiral cloned CO2H cofactor compounds conversion cyanohydrins deamination decarboxylase dehalogenase dehydrogenase deracemization derivatives dioxygenase directed evolution drug dynamic kinetic resolution enantiomeric enantiomers enantioselective enzymatic enzyme epoxide ester esterase ethyl Figure formation genes glucose haloalkane hydrolase hydrolysis hydroxylation immobilized inhibitors intermediate isolated ketones kinetic resolution lipase lipase-catalyzed lyase method microbial Microbiol monooxygenase mutagenesis mutant NADH NH2 NH2 nitrilase nitrile nucleosides OH OH OH optically active organic solvents oxidase oxidation pharmaceutical preparation production protein Pseudomonas purified pyruvate racemic reaction recombinant reductase reduction regeneration regioselective resolution of racemic Rhodococcus Scheme screening selective sequence stereoselective strain structure substrate substrate specificity synthetic Tetrahedron Asymmetry whole cells yeast yield