The Biological Chemistry of the Elements: The Inorganic Chemistry of Life

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OUP Oxford, Aug 16, 2001 - Medical - 575 pages
2 Reviews
Twenty inorganic elements, mostly metal ions, are consistently found in living systems and are essential for living systems to function correctly. The aim of this text is to discuss, describe, and explain the functional relevance of those elements: the reasons for their selection; the processes of their uptake, transport and final localization in cells; the regulation of these processes; and the interactive network of their reactions that connects the in vivo inorganic elements to the environment and to the genome. The first seven chapters describe the physical, chemical, and biological principles of the involvement of the elements in cellular activity, stressing how inorganic and organic chemicals react differently together in different compartments. The next twelve chapters describe the uses of the individual essential inorganic elements and a section on the genetic control of each element is included. The final chapter discusses how the interaction of genes, proteins, small molecules, and inorganic elements plays an important role in evolution and the speciation of organisms. The second edition of 'The Biological Chemistry of The Elements' has been thoroughly revised in content and style. The main additions to the first edition concern the discussion of the links to the genome of the uptake and transfer of inorganic elements and the regulation of homeostasis, the functional co-operative activities of the elements, the interaction with the environment, and the evolution of usage. Recent structural and mechanistic knowledge of many biomolecules and organelles are also included. Like the higly praised first edition, this text will be the bible of bioinorganic chemistry.
 

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Contents

The principles of the uptake
30
Kinetic effects and control
62
Redox incorporation of anions
72
cation and anion
74
systems
80
Special solution condititions in vesicles
98
Kinetic considerations of chemical
108
Energy in biological systems and hydrogen
135
Lewis acid catalysis and regulation
315
redox reactions
342
coupled redox reactions
374
dioxygen evolution
400
extracytoplasmic oxidases
418
remnants of early life?
436
Molybdenum tungsten vanadium
450
acidbase
471

Proton migration coupled to redox reactions
141
The role of biological macromolecules
154
Summary of genetic control and regulation
194
The roles of individual elements
229
controls and triggers
278
redox
489
The biochemistry of selenium
497
elements
552
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About the author (2001)

J.J.R. Frausto da Silva is a Professor of Analytical Chemistry, Instituto Superior Tecnico, Universidad Tecnicia de Lisboa. R.J.P. Williams is an Emeritus Professor of Chemistry, University of Oxford.

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