The Biology of Oligodendrocytes
Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
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2 Comparative biology of Schwann cells and oligodendrocytes
3 Control of oligodendrocyte development and myelination in the vertebrate CNS
4 Molecular organization of the oligodendrocyte and myelin
5 The genetics of oligodendrocytes
6 Immunobiology of the oligodendrocyte
repair remyelination and stem cells
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Acad Sci USA activation adhesion molecule adult AMPA antibodies apoptosis astrocytes autoimmune axons brain Cell Biol central nervous system chronic CNS myelin compact myelin culture cytes cytoplasm damage deﬁned demyelination dendrocytes differentiation disease domains drocytes encephalomyelitis excitotoxicity Exp Neurol expression extracellular ﬁbers ﬁrst function gene Glia glial cells glutamate receptors glutamate transporters growth factor human identiﬁed induced inﬂammation inﬂammatory inhibitor inhibits integrin interactions lesions macrophages mechanisms mediate mice microglia migration miRNAs molecular mouse mRNA multiple sclerosis mutant myelin basic protein myelin internode myelin proteins myelin repair myelin-associated glycoprotein Natl Acad Sci neuregulin neurite neurons Neurosci Neurosci Res NG2+ cells NMDA receptors nodes of Ranvier NRG1 oligo oligoden oligodendro oligodendrocyte precursor oligodendroglial OPCs optic nerve paranodal loops pathways Proc Natl Acad proliferation regulation role Schwann cells signaling signiﬁcant speciﬁc spinal cord injury stem cells studies target tion Trapp upregulated vivo white matter