The Biology of Oligodendrocytes

Couverture
Patricia Armati, Emily Mathey
Cambridge University Press, 21 oct. 2010
Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions.
 

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Table des matières

1 CNS oligarchs the rise of the oligodendrocyte in a neuroncentric culture
1
2 Comparative biology of Schwann cells and oligodendrocytes
19
3 Control of oligodendrocyte development and myelination in the vertebrate CNS
49
4 Molecular organization of the oligodendrocyte and myelin
64
5 The genetics of oligodendrocytes
103
6 Immunobiology of the oligodendrocyte
115
repair remyelination and stem cells
137
8 Glial progenitor cells and the dynamics of the oligodendrocyte and its myelin in the aged and injured CNS
154
9 Oligodendroglial pathology in multiple sclerosis
171
10 Glutamate receptors transporters and periventricular leukomalacia
186
References
202
Index
278
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À propos de l'auteur (2010)

Patricia Armati is Associate Professor of Neuroscience and co-director of the Nerve Research Foundation, Brain and Mind Research Institute at the University of Sydney, Australia. She has a long standing interest in the cells of the nervous system and the relationship to disease and is editor of The Biology of Schwann Cells (Cambridge University Press, 2007).

Emily Mathey is a postdoctoral scientist at the Brain and Mind Research Institute at the University of Sydney. She has a keen interest in both immunology and neurobiology with particular emphasis on pathogenic antibody responses in demyelinating disease of the peripheral and central nervous systems.

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