Introduction to Complexity and Complex Systems

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CRC Press, Oct 7, 2014 - Medical - 551 pages
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The boundaries between simple and complicated, and complicated and complex system designations are fuzzy and debatable, even using quantitative measures of complexity. However, if you are a biomedical engineer, a biologist, physiologist, economist, politician, stock market speculator, or politician, you have encountered complex systems. Furthermore, your success depends on your ability to successfully interact with and manage a variety of complex systems. In order not to be blindsided by unexpected results, we need a systematic, comprehensive way of analyzing, modeling, and simulating complex systems to predict non-anticipated outcomes.

In its engaging first chapters, the book introduces complex systems, Campbell's Law, and the Law of Unintended Consequences, and mathematics necessary for conversations in complex systems. Subsequent chapters illustrate concepts via commonly studied biological mechanisms. The final chapters focus on higher-level complexity problems, and introduce complexity in economic systems.

Designed as a reference for biologists and biological engineers, Introduction to Complexity and Complex Systems lends itself to use in a classroom course to introduce advanced students studying biomedical engineering, biophysics, or physiology to complex systems. Engaging and illustrative, this book aids scientists and decision makers in managing biological complexity and complex systems.

 

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Contents

1 Introduction to Complexity and Complex Systems
1
2 Introduction to Large Linear Systems
23
3 Introduction to Biochemical Oscillators and Complex Nonlinear Biochemical Systems
67
4 Modularity Redundancy Degeneracy Pleiotropy and Robustness in Complex Biological Systems
135
Invertebrate Immune Systems
169
6 Complex Adaptive and Innate Human Immune Systems
197
7 Complexity in Quasispecies and MicroRNAs
239
Examples of Models of Some Complex Physiological Systems
251
11 Introduction to Complexity in Economic Systems
345
12 Dealing with Complexity
369
Simnon Programs Used in Chapters 3 and 8
379
How to Use Root Locus to Determine the Stability of SISO Linear Control Systems
407
Bode Plots
419
Nyquist Plots
425
Glossary
427
Bibliography and Related Readings
489

9 Quest for Quantitative Measures of Complexity
323
10 Irreducible and Specified Complexity in Living Systems
335
Back Cover
521
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About the author (2014)

Robert B. Northrop is Professor Emeritus and the former Program Director of the Biomedical Engineering Graduate Program at the University of Connecticut.

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