Antonio M. Gotto
Butterworth-Heinemann Limited, 1987 - Medical - 405 pages
In this rapidly evolving field of research, an enormous amount of new knowledge of lipoprotein structure, function and metabolism has emerged. The 1985 Nobel Prize-winning pioneering work of Brown and Goldstein on the LDL receptor has had a profound impact on developments in the field. This work is one of the many subjects reviewed in detail in this book. The volume begins with chapters on structure, then proceeds to analysis of lipid and lipoprotein dynamics, metabolism, function, genetics, and molecular biology. Lipoprotein genetics in molecular biology, the role of lipoprotein receptors, and Lp(a) - a topic underrepresented in volumes on lipoproteins, are another three such topics in an impressive volume. This work will mainly be of interest to researchers interested in lipid and lipoprotein structure and metabolism, but will also be of great value to clinical medicine and biology in general.
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Structural features of triglyceriderich lipoproteins and physicalchemical properties of their
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3-VLDL receptor Acad acetyl-LDL receptor Acta activity acyl chains Albers amino acid apo(a apoA-I apoB apoCII apoE apolipoproteins Arteriosclerosis association Atherosclerosis binding Biochemistry Biochim Biol Biophys catabolism cells CETP Chem cholesterol content cholesteryl ester cholesteryl oleate chylomicrons chylomicrons and VLDL Clin components composition concentration containing degradation density discoidal DMPC emulsions enzyme fatty acids fibroblasts fraction gene genetic Goldstein Gotto HDL particles HDL2 HDL3 hepatic lipase HTG-VLDL human hydrophobic hypertriglyceridemia hypertriglyceridemic increased incubation Innerarity intestinal Invest LCAT LDL receptor lecithin levels ligand Lipid Res lipid transfer lipolysis lipoprotein lipase liver Lp(a lymph macrophages Mahley membranes metabolism molecular molecules nascent Natl Nestel nonpolar lipid normal pathway Patsch peptides phosphatidylcholine phospholipid Pownall Proc protein ratio reductase region removal residues sequence specific structure studies subfractions substrate surface phase synthesis teins tion tissues transfer proteins triglyceride triglyceride-rich lipoproteins triolein uptake vesicles vitro vivo VLDL WHHL