The Laboratory Computer: A Practical Guide for Physiologists and Neuroscientists

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Academic Press, Jul 24, 2001 - Computers - 354 pages
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The Laboratory Computer: A Practical Guide for Physiologists and Neuroscientists introduces the reader to both the basic principles and the actual practice of recording physiological signals using the computer.

It describes the basic operation of the computer, the types of transducers used to measure physical quantities such as temperature and pressure, how these signals are amplified and converted into digital form, and the mathematical analysis techniques that can then be applied. It is aimed at the physiologist or neuroscientist using modern computer data acquisition systems in the laboratory, providing both an understanding of how such systems work and a guide to their purchase and implementation.



  • The key facts and concepts that are vital for the effective use of computer data acquisition systems
  • A unique overview of the commonly available laboratory hardware and software, including both commercial and free software
  • A practical guide to designing one's own or choosing commercial data acquisition hardware and software
 

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Contents

Introduction
1
11 THE RISE OF THE LABORATORY COMPUTER
2
12 THE DATA ACQUISITION SYSTEM
4
13 ANALYSING DIGITISED SIGNALS
7
14 ANALYSIS OF ELECTROPHYSIOLOGICAL SIGNALS
8
15 IMAGE ANALYSIS
10
17 SUMMARY
11
The Personal Computer
12
68 FURTHER READING
171
Recording and Analysis of Intracellular Electrophysiological Signals
172
71 ORIGIN OF BIOELECTRICAL SIGNALS
173
72 CELL EQUIVALENT CIRCUITS
174
73 INTRACELLULAR RECORDING TECHNIQUES
175
74 THE INTRACELLULAR DATA ACQUISITION SYSTEM
179
75 EXPERIMENTAL PARADIGMS
184
76 ANALYSIS OF VOLTAGEACTIVATED CURRENTS
186

22 MAIN COMPONENTS OF A COMPUTER SYSTEM
14
23 THE CENTRAL PROCESSING UNIT
17
24 RANDOM ACCESS MEMORY
19
25 CACHE MEMORY
20
26 MOTHERBOARDS
21
27 MAGNETIC DISC STORAGE
22
28 REMOVABLE DISC STORAGE
25
29 INTERFACE BUSES AND EXPANSION SLOTS
27
210 INPUT DEVICES
29
211 VIDEO DISPLAYS
30
212 PERIPHERAL DEVICE INTERFACES
33
213 PRINTERS AND OTHER OUTPUT DEVICES
35
214 OPERATING SYSTEMS
37
215 COMPUTER NETWORKS
43
216 FURTHER READING
44
Digital Data Acquisition
45
31 DIGITISING ANALOGUE SIGNALS
46
32 THE NYQUIST CRITERION
47
33 THE AD CONVERTER
48
34 THE LABORATORY INTERFACE UNIT
52
35 LABORATORY INTERFACEHOST COMPUTER CONNECTIONS
54
36 LABORATORY INTERFACES AND SUPPLIERS
59
37 RECORDING MODES
67
38 DATA ACQUISITION SOFTWARE
70
39 CHOOSING A DATA ACQUISITION SYSTEM
72
310 FURTHER READING
73
Signal Conditioning
74
41 AMPLIFIERS
75
42 ANALOGUE FILTERING
83
43 EVENT DETECTORS
88
44 SIGNAL CONDITIONERS
89
45 INTERFERENCE AND ITS ELIMINATION
92
46 STIMULATORS
97
47 FURTHER READING
99
Transducers and Sensors
101
51 BASIC TRANSDUCER PROPERTIES
102
52 TEMPERATURE TRANSDUCERS
104
53 LIGHT DETECTORS
107
54 FORCE TRANSDUCERS
115
55 PRESSURE TRANSDUCERS
121
56 CHEMICAL SENSORS
125
57 FURTHER READING
135
Signal Analysis and Measurement
136
62 BASIC WAVEFORM CHARACTERISTICS
140
63 SIGNAL AVERAGING
143
64 DIGITAL FILTERS
145
65 FREQUENCY DOMAIN ANALYSIS
147
66 CURVE FITTING
155
67 ANALYSIS OF RANDOM DISTRIBUTIONS
168
77 ANALYSIS OF SYNAPTIC SIGNALS
194
78 SINGLECHANNEL CURRENTS
203
79 NOISE ANALYSIS
214
710 CELL CAPACITANCE
221
711 FURTHER READING
225
Recording and Analysis of Extracellular Electrophysiological Signals
226
82 RECORDING ELECTRODES
228
83 ELECTROMYOGRAPHY
229
84 ELECTROCARDIOGRAPHY
231
85 ELECTROENCEPHALOGRAPHY
238
86 RECORDING ACTIVITY OF SINGLE NEURONS
241
87 ANALYSIS OF NEURAL SPIKE TRAINS
249
88 NEURAL SIGNAL ACQUISITION SYSTEMS
255
89 FURTHER READING
260
Image Analysis
261
91 DIGITISATION OF IMAGES
262
92 IMAGE ACQUISITION DEVICES
267
94 CCD READOUT ARCHITECTURES
269
95 CCD PERFORMANCE
270
96 ELECTRONIC CAMERAS
271
97 ANALOGUE VIDEO SIGNAL FORMATS
272
98 ANALOGUE VIDEO CAMERAS
274
910 DIGITISING ANALOGUE VIDEO SIGNALS
276
911 DIGITAL CAMERAS
278
912 DIGITAL FRAME GRABBERS
281
914 CONFOCAL MICROSCOPY
284
915 IMAGE ANALYSIS
286
916 IMAGE CALIBRATION
288
917 IMAGE ARITHMETIC
290
918 SPATIAL FILTERING
291
920 ANALYSIS OF MOVING IMAGES
294
921 THREEDIMENSIONAL IMAGING
296
922 FURTHER READING
297
Software Development
299
101 COMPUTER PROGRAMS
300
103 PROGRAMMING LANGUAGE FEATURES
301
104 USER INTERFACE DESIGN
306
105 SOFTWARE DEVELOPMENT TOOLS
308
107 BORLAND DELPHI
313
108 VISUAL C++
315
109 MULTIPLATFORM SOFTWARE DEVELOPMENT
317
1011 LABVIEW
321
1012 CHOOSING A DEVELOPMENT SYSTEM
323
1013 FURTHER READING
325
References
326
Suppliers
337
Index
341
Copyright

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Page 333 - Macaulay, RJ, Caudill, MA, Kutz, I., Adam, D., Gordon, D., Kilborn, KM, Barger, AC, Shannon, DC, Cohen, RJ, and Benson, H.
Page 329 - KATZ, B. (1954). The effect of magnesium on the activity of motor nerve endings.
Page 336 - Voss, A., Kurths, J., Kleiner, HJ, Witt, A., Wessel, N., Saparin, P., Osterziel, KJ, Schurath, R., Dietz, R.: The application of methods of non-linear dynamics for the improved and predictive recognition of patients threatened by sudden cardiac death.
Page 332 - Myoelectric manifestations of fatigue in voluntary and electrically elicited contractions .J Appi Physiol 69: 1810-1820.
Page 336 - Electrocardiograms that represent the potential variations of a single electrode.
Page 327 - Currents through the fusion pore that forms during exocytosis of a secretory vesicle. Nature 328: 814-817 11.
Page 334 - A quantitative analysis of local anaesthetic alteration of miniature end-plate currents and end-plate current fluctuations. J. Physiol.
Page 334 - Sachs F., Neil J., and Barkakati N. (1982) The automated analysis of data from single ionic channels. Pflugers Arch. 395, 331-340. Sakmann B. and Neher E. (eds.) (1983a) Single-Channel Recording (Plenum, New York).
Page 335 - THOMAS, RC (1978). Ion-sensitive Intracellular Microelectrodes: How to Make and Use Them.

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