Cruciferous Vegetables, Isothiocyanates and Indoles
International Agency for Research on Cancer, IARC Working Group on the Evaluation of Cancer-Preventive Strategies
IARC, 2004 - Business & Economics - 262 pages
There is evidence that cruciferous vegetables at levels relevant to human intake or more can inhibit neoplastic and preneoplastic responses in experimental animals mainly when given simultaneously with carcinogens or throughout the experiment. The findings of this Handbook should encourage the promotion of cruciferous vegetable consumption as a part of a diet containing a variety of fruit and vegetables to reduce cancer risk and improve health.
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Glucosinolates isothiocyanates and indoles
Metabolism kinetics and genetic variation
Cancer preventive effects
Other beneficial effects of cruciferous
List of abbreviations
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Cruciferous Vegetables, Isothiocyanates and Indoles IARC Working Group on ...
No preview available - 2004
3,32-diindolylmethane aberrant crypt foci acid activity aflatoxin agent allyl-ITC animals antioxidant apoptosis benzo[a]pyrene benzyl-ITC biomarkers Bjeldanes Brassica breast cancer broccoli Brussels sprouts bw per day cabbage cancer-preventive carbinol carcino carcinogen carcinogenesis case-control study CD CD cell lines Chem chemopreventive Chung cohort studies colon compounds concentration conjugates consumption cruciferous vegetable intake cruciferous vegetables cyanates cytochrome P450 decreased diet containing dietary DMBA DNA adducts dose enzymes estradiol estrogen etal evaluated excretion fenale Fischer 344 rats frequenry gavage gene given glucosinolates glutathione groups hepatic human IARC increased indole-3 indole-3-carbinol indoles induced inhibited inhibitory intestine inverse association isothio liver lung mammary metabolism metabolites mg/kg bw mice mouse mutagenic myrosinase oral phase II enzymes phenethyl phenethyl-ITC PhIP prostate protein receptor reduced risk significant sinigrin sulforaphane tion toxicity Toxicol treatment tumorigenesis tumour tumour incidence umol umol/l urinary urine vitro weeks Zhang