Cruciferous Vegetables, Isothiocyanates and IndolesThere is evidence that cruciferous vegetables at levels relevant to human intake or more can inhibit neoplastic and preneoplastic responses in experimental animals mainly when given simultaneously with carcinogens or throughout the experiment. The findings of this Handbook should encourage the promotion of cruciferous vegetable consumption as a part of a diet containing a variety of fruit and vegetables to reduce cancer risk and improve health. |
Contents
Metabolism kinetics and genetic variation | 13 |
210 | 181 |
Biochemical genetics of glucosinolate | 191 |
Factors that affect glucosinolate | 213 |
Other beneficial effects of cruciferous | 248 |
Carcinogenicity | 256 |
Other editions - View all
Cruciferous Vegetables, Isothiocyanates and Indoles IARC Working Group on ... No preview available - 2004 |
Common terms and phrases
3,3'-diindolylmethane aberrant crypt foci acid activity aflatoxin aflatoxin B₁ agent allyl-ITC animals apoptosis azoxymethane benzo[a]pyrene benzyl-ITC biomarkers Bjeldanes body mass index Brassica breast cancer broccoli Brussels sprouts bw per day cabbage carbinol carcinogen carcinogenesis case-control study cauliflower cell lines Chem chemopreventive cohort studies colon compounds concentration conjugates controls cruciferous vegetable intake cruciferous vegetables cyanates cytochrome P450 decreased diet containing dietary DMBA DNA adducts dose effects enzymes estrogen excretion exposure female Fischer 344 rats gavage gene glucosinolates glutathione GSTM1 hepatic human increased indole-3 indole-3-carbinol indoles induced inhibited inhibitory inverse association isothio isothiocyanates liver male metabolism metabolites mg/kg bw mice mouse multiplicity mutagenicity myrosinase NQO1 oral phase II enzymes phenethyl phenethyl-ITC PhIP Population-based prostate protein receptor reduced Relative risk sinigrin smoking sulforaphane Table tion toxicity Toxicol treatment tumorigenesis tumour tumour incidence urinary urine vitro weeks Zhang µmol µmol/l