Cruciferous Vegetables, Isothiocyanates and Indoles
International Agency for Research on Cancer, IARC Working Group on the Evaluation of Cancer-Preventive Strategies, World Health Organization
IARC, 2004 - Business & Economics - 262 pages
There is evidence that cruciferous vegetables at levels relevant to human intake or more can inhibit neoplastic and preneoplastic responses in experimental animals mainly when given simultaneously with carcinogens or throughout the experiment. The findings of this Handbook should encourage the promotion of cruciferous vegetable consumption as a part of a diet containing a variety of fruit and vegetables to reduce cancer risk and improve health.
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Biochemical genetics of glucosinolate
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Cruciferous Vegetables, Isothiocyanates and Indoles IARC Working Group on ...
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acid activity adducts administration aflatoxin agent animals apoptosis assessment association benzyl-ITC breast broccoli Brussels sprouts cabbage cancer carbinol carcinogen carcinogenesis case-control study cells cohort colon compounds concentration conjugates consumption containing controls cruciferous vegetables crypt cyanates decreased derived diet dietary DMBA dose effects enzymes estrogen et al evaluated evidence exposure expression factors female Fischer 344 foci formation gavage gene given glucosinolates growth hepatic human incidence increased indole-3 indole-3-carbinol indoles induced inhibited inhibitory initiation intake interview inverse isothio isothiocyanates Italy levels liver lung male mammary mechanisms metabolism metabolites mg/kg bw mice mouse multiplicity observed oral organs phase phenethyl-ITC preventive protein rats reduced Relative reported response risk showed significant significantly smoking species sulforaphane Table tion treated treatment tumour umol umol/l urinary urine weeks weight women