Wound Healing, Tissue Repair, and Regeneration in Diabetes

Front Cover
Debasis Bagchi, Amitava Das, Sashwati Roy
Elsevier, May 8, 2020 - Health & Fitness - 638 pages

Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions.

This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals.



  • Explains diabetic wounds and their complications
  • Assesses the role of nutraceuticals, herbal supplements and other modalities for use in treating diabetic wounds
  • Provides protocols for diabetic wound management
 

Contents

The diabetic foot
3
Role of oxidants and antioxidants in diabetic wound healing
13
Hallmarks of diabetic foot ulcers
33
Suman Santra Atul Rawat Dhamotharan Pattarayan Sashwati
39
An insight into the pathophysiology
49
Nociception assays
55
Diabetic neuropathy clinical research trials
61
References
73
Conclusions
383
Acknowledgments
384
References
385
337
391
Collagen in diabetic wound healing
393
Collagen in diabetic wounds
394
Diabeticwoundinfectioninduced collagen dysfunction
396
Applications of collagen in wound healing
397

Dysregulated inflammation in diabetic wounds
91
8
149
Biomaterials for diabetic woundhealing therapies Nava P Rijal Daria A Narmoneva 1 Introduction
168
Role of cytokines and chemokines in wound healing
197
161
225
References
228
The wound microbiome
237
Highthroughput sequencing approaches
245
Future directions
251
Downregulation of hexose sugar metabolism in diabetes
259
Successes and challenges in the use of biomaterials for the management of diabetic wounds
275
Biomaterials for dermal tissue engineering and regeneration
276
Emerging biomaterial technologies for treatment of diabetic wounds
294
168
295
Conclusions
296
References
297
171
303
Photobiomodulation therapy in diabetic wound healing Sasikumar Ponnusamy Rodrigo Mosca Karishma Desai Praveen Arany
305
Light as a therapeutic intervention
306
Mechanisms of photobiomodulation therapy
307
PBM therapy in diabetic wound healing 1 2 3 4 Optimizing PBM treatments to dysregulated signaling pathways in diabetic wound healing
311
Implications for PBM therapy in diabetes wounds and associated fibrosis and cancers
316
References
317
Angiogenic response in wound healing
319
Therapeutic benefits of treating chronic diabetic wounds with placental membrane allografts Jaideep Banerjee Sandeep Dhall 1 History of placental ti...
323
Preservation techniques of placental membranes for commercial use 2
324
Benefits of placental allografts in chronic wound repair
327
Experimental evidence of wound repair by placental membrane in animal models
328
5
330
References
332
Debridement and negative pressure wound therapy Said A Atway Nicholas V DiMassa 273 273 275 276 294 296 297 305 306 307 311 323 323 32...
337
Debridement
341
Negativepressure wound therapy
343
Unique clinical usage and future applications
352
Safety and conclusion
353
Protease technology in wound repair
357
Risk factors for primary and recurrent DFUs
358
Dynamics of wound repair and tissue regeneration
359
Protease therapy
360
Protease therapy for DFUs
362
Chronic inflammation impedes or stalls wound repair and regeneration
367
Role of protease in wound infection
369
Emerging uses of protease therapy
373
References
399
Nutrition and diabetic wound healing
403
Dysregulated wound inflammation during diabetes
404
Other nutritional interventions
407
A natural remedy for diabetic wounds
408
Conclusion
410
345
411
Nanotechnology and nanocarriers in wound healing
415
Drugdelivery nanocarriers for skin woundhealing applications
439
175
473
References
478
197
480
Potential biomarkers for improved
491
Classification of bacterial VOCs by functional groups
498
10
504
Further reading
512
Novel concepts in diabetic wound healing
513
Tissue regeneration and reprogramming
515
Cells of tissue regeneration
517
Role of ECM in tissue regeneration
521
Epigenetics of tissue regeneration
523
198
524
Conclusion
525
Bone marrow monopoiesis and wound healing in diabetes
535
MoMϕ dysregulation and impaired wound healing in diabetes
537
Ontogeny of tissue mononuclear phagocytes and blood Mo in homeostasis
538
Origin of wound Mϕ
539
Tissue injury and monopoiesis
541
Diabetesinduced HSPC modifications
542
Potential mechanisms underlying HSPC alterations in diabetic bone marrow
543
Signaling pathways involved in obesity and diabetesassociated increases in monopoiesis
544
Effect of diabetes on skin woundinginduced monocyte expansion in bone marrow
545
Conclusions implications and future directions
547
Funding
548
Role of mesenchymal stem cells in diabetic wound healing
555
MicroRNAs in diabetes
557
Wound healing
579
References
587
Index
593
223
594
259
600
439
607
Copyright

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About the author (2020)

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Amitava Das, PhD is a Post-Doctoral Researcher in the Department of Surgery, Davis Heart & Lung Research Institute, The Ohio State University Medical Center, Columbus. Dr. Das earned his bachelors, masters in Pharmacy and Pharmaceutical Chemistry respectively from PES College of Pharmacy, Bangalore, India. He earned his PhD degree in Human Nutrition from The Ohio State University in 2016 after which he joined as a post-doctoral researcher in Department of Surgery at The Ohio State University Medical Center, Columbus. His research interests are wound healing, tissue repair and regeneration in diabetes with an emphasis on Nutraceuticals. He has published over 25 research papers and book chapters. He has presented at various national and international conferences and is the recipients of several awards.

Sashwati Roy, PhD is a Professor of Surgery and Director of Laser Capture Molecular Analysis facility at the Ohio State University Columbus Ohio. She received her PhD in 1994 in Physiology and Environmental Sciences. She completed her postdoctoral training from University of California, Berkeley. Her research interest include wound inflammation, mechanisms of resolution of diabetic wound inflammation, role of miRNA in tissue repair processes. Dr. Roy has over 150 peer review publications in high impact journals including Nature Nanotechnology, PNAS and Journal of Immunology. Dr. Roy is the President Elect of the Wound Healing Society. She serves in the Editorial Board of several Journals such as Physiological Genomics, Antioxidants and Redox Signaling. She is an expert in significance of macrophage and inflammation in chronic wounds. Dr. Roy's research is funded by National Institute of Health (NIDDK, NIH).

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