Wound Healing, Tissue Repair, and Regeneration in Diabetes

Debasis Bagchi, Amitava Das, Sashwati Roy

Elsevier, May 8, 2020 - Health & Fitness - 638 pages

Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions.

This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals.

• Explains diabetic wounds and their complications
• Assesses the role of nutraceuticals, herbal supplements and other modalities for use in treating diabetic wounds
• Provides protocols for diabetic wound management

Contents

• The diabetic foot: 3
• Role of oxidants and antioxidants in diabetic wound healing: 13
• Hallmarks of diabetic foot ulcers: 33
• Suman Santra Atul Rawat Dhamotharan Pattarayan Sashwati: 39
• An insight into the pathophysiology: 49
• Nociception assays: 55
• Diabetic neuropathy clinical research trials: 61
• References: 73
• Dysregulated inflammation in diabetic wounds: 91
• 8: 149
• Biomaterials for diabetic woundhealing therapies Nava P Rijal Daria A Narmoneva 1 Introduction: 168
• Role of cytokines and chemokines in wound healing: 197
• 161: 225
• References: 228
• The wound microbiome: 237
• Highthroughput sequencing approaches: 245
• Future directions: 251
• Downregulation of hexose sugar metabolism in diabetes: 259
• Successes and challenges in the use of biomaterials for the management of diabetic wounds: 275
• Biomaterials for dermal tissue engineering and regeneration: 276
• Emerging biomaterial technologies for treatment of diabetic wounds: 294
• 168: 295
• Conclusions: 296
• References: 297
• 171: 303
• Photobiomodulation therapy in diabetic wound healing Sasikumar Ponnusamy Rodrigo Mosca Karishma Desai Praveen Arany: 305
• Light as a therapeutic intervention: 306
• Mechanisms of photobiomodulation therapy: 307
• PBM therapy in diabetic wound healing 1 2 3 4 Optimizing PBM treatments to dysregulated signaling pathways in diabetic wound healing: 311
• Implications for PBM therapy in diabetes wounds and associated fibrosis and cancers: 316
• References: 317
• Angiogenic response in wound healing: 319
• Therapeutic benefits of treating chronic diabetic wounds with placental membrane allografts Jaideep Banerjee Sandeep Dhall 1 History of placental ti...: 323
• Preservation techniques of placental membranes for commercial use 2: 324
• Benefits of placental allografts in chronic wound repair: 327
• Experimental evidence of wound repair by placental membrane in animal models: 328
• 5: 330
• References: 332
• Debridement and negative pressure wound therapy Said A Atway Nicholas V DiMassa 273 273 275 276 294 296 297 305 306 307 311 323 323 32...: 337
• Debridement: 341
• Negativepressure wound therapy: 343
• Unique clinical usage and future applications: 352
• Safety and conclusion: 353
• Protease technology in wound repair: 357
• Risk factors for primary and recurrent DFUs: 358
• Dynamics of wound repair and tissue regeneration: 359
• Protease therapy: 360
• Protease therapy for DFUs: 362
• Chronic inflammation impedes or stalls wound repair and regeneration: 367
• Role of protease in wound infection: 369
• Emerging uses of protease therapy: 373
• Conclusions: 383
• Acknowledgments: 384
• References: 385
• 337: 391
• Collagen in diabetic wound healing: 393
• Collagen in diabetic wounds: 394
• Diabeticwoundinfectioninduced collagen dysfunction: 396
• Applications of collagen in wound healing: 397
• References: 399
• Nutrition and diabetic wound healing: 403
• Dysregulated wound inflammation during diabetes: 404
• Other nutritional interventions: 407
• A natural remedy for diabetic wounds: 408
• Conclusion: 410
• 345: 411
• Nanotechnology and nanocarriers in wound healing: 415
• Drugdelivery nanocarriers for skin woundhealing applications: 439
• 175: 473
• References: 478
• 197: 480
• Potential biomarkers for improved: 491
• Classification of bacterial VOCs by functional groups: 498
• 10: 504
• Further reading: 512
• Novel concepts in diabetic wound healing: 513
• Tissue regeneration and reprogramming: 515
• Cells of tissue regeneration: 517
• Role of ECM in tissue regeneration: 521
• Epigenetics of tissue regeneration: 523
• 198: 524
• Conclusion: 525
• Bone marrow monopoiesis and wound healing in diabetes: 535
• MoMϕ dysregulation and impaired wound healing in diabetes: 537
• Ontogeny of tissue mononuclear phagocytes and blood Mo in homeostasis: 538
• Origin of wound Mϕ: 539
• Tissue injury and monopoiesis: 541
• Diabetesinduced HSPC modifications: 542
• Potential mechanisms underlying HSPC alterations in diabetic bone marrow: 543
• Signaling pathways involved in obesity and diabetesassociated increases in monopoiesis: 544
• Effect of diabetes on skin woundinginduced monocyte expansion in bone marrow: 545
• Conclusions implications and future directions: 547
• Funding: 548
• Role of mesenchymal stem cells in diabetic wound healing: 555
• MicroRNAs in diabetes: 557
• Wound healing: 579
• References: 587
• Index: 593
• 223: 594
• 259: 600
• 439: 607

About the author

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Amitava Das, PhD is a Post-Doctoral Researcher in the Department of Surgery, Davis Heart & Lung Research Institute, The Ohio State University Medical Center, Columbus. Dr. Das earned his bachelors, masters in Pharmacy and Pharmaceutical Chemistry respectively from PES College of Pharmacy, Bangalore, India. He earned his PhD degree in Human Nutrition from The Ohio State University in 2016 after which he joined as a post-doctoral researcher in Department of Surgery at The Ohio State University Medical Center, Columbus. His research interests are wound healing, tissue repair and regeneration in diabetes with an emphasis on Nutraceuticals. He has published over 25 research papers and book chapters. He has presented at various national and international conferences and is the recipients of several awards.

Sashwati Roy, PhD is a Professor of Surgery and Director of Laser Capture Molecular Analysis facility at the Ohio State University Columbus Ohio. She received her PhD in 1994 in Physiology and Environmental Sciences. She completed her postdoctoral training from University of California, Berkeley. Her research interest include wound inflammation, mechanisms of resolution of diabetic wound inflammation, role of miRNA in tissue repair processes. Dr. Roy has over 150 peer review publications in high impact journals including Nature Nanotechnology, PNAS and Journal of Immunology. Dr. Roy is the President Elect of the Wound Healing Society. She serves in the Editorial Board of several Journals such as Physiological Genomics, Antioxidants and Redox Signaling. She is an expert in significance of macrophage and inflammation in chronic wounds. Dr. Roy's research is funded by National Institute of Health (NIDDK, NIH).

Bibliographic information

• Title: Wound Healing, Tissue Repair, and Regeneration in Diabetes
• Editors: Debasis Bagchi, Amitava Das, Sashwati Roy
• Publisher: Elsevier, 2020
• ISBN: 0128164131, 9780128164136
• Length: 638 pages
• Subjects: Health & Fitness / Diet & Nutrition / Nutrition