Wound Healing, Tissue Repair, and Regeneration in DiabetesDebasis Bagchi, Amitava Das, Sashwati Roy Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals.
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Contents
The diabetic foot | 3 |
Role of oxidants and antioxidants in diabetic wound healing | 13 |
Hallmarks of diabetic foot ulcers | 33 |
Suman Santra Atul Rawat Dhamotharan Pattarayan Sashwati | 39 |
An insight into the pathophysiology | 49 |
Nociception assays | 55 |
Diabetic neuropathy clinical research trials | 61 |
References | 73 |
Conclusions | 383 |
Acknowledgments | 384 |
References | 385 |
337 | 391 |
Collagen in diabetic wound healing | 393 |
Collagen in diabetic wounds | 394 |
Diabeticwoundinfectioninduced collagen dysfunction | 396 |
Applications of collagen in wound healing | 397 |
Dysregulated inflammation in diabetic wounds | 91 |
8 | 149 |
Biomaterials for diabetic woundhealing therapies Nava P Rijal Daria A Narmoneva 1 Introduction | 168 |
Role of cytokines and chemokines in wound healing | 197 |
161 | 225 |
References | 228 |
The wound microbiome | 237 |
Highthroughput sequencing approaches | 245 |
Future directions | 251 |
Downregulation of hexose sugar metabolism in diabetes | 259 |
Successes and challenges in the use of biomaterials for the management of diabetic wounds | 275 |
Biomaterials for dermal tissue engineering and regeneration | 276 |
Emerging biomaterial technologies for treatment of diabetic wounds | 294 |
168 | 295 |
Conclusions | 296 |
References | 297 |
171 | 303 |
Photobiomodulation therapy in diabetic wound healing Sasikumar Ponnusamy Rodrigo Mosca Karishma Desai Praveen Arany | 305 |
Light as a therapeutic intervention | 306 |
Mechanisms of photobiomodulation therapy | 307 |
PBM therapy in diabetic wound healing 1 2 3 4 Optimizing PBM treatments to dysregulated signaling pathways in diabetic wound healing | 311 |
Implications for PBM therapy in diabetes wounds and associated fibrosis and cancers | 316 |
References | 317 |
Angiogenic response in wound healing | 319 |
Therapeutic benefits of treating chronic diabetic wounds with placental membrane allografts Jaideep Banerjee Sandeep Dhall 1 History of placental ti... | 323 |
Preservation techniques of placental membranes for commercial use 2 | 324 |
Benefits of placental allografts in chronic wound repair | 327 |
Experimental evidence of wound repair by placental membrane in animal models | 328 |
5 | 330 |
References | 332 |
Debridement and negative pressure wound therapy Said A Atway Nicholas V DiMassa 273 273 275 276 294 296 297 305 306 307 311 323 323 32... | 337 |
Debridement | 341 |
Negativepressure wound therapy | 343 |
Unique clinical usage and future applications | 352 |
Safety and conclusion | 353 |
Protease technology in wound repair | 357 |
Risk factors for primary and recurrent DFUs | 358 |
Dynamics of wound repair and tissue regeneration | 359 |
Protease therapy | 360 |
Protease therapy for DFUs | 362 |
Chronic inflammation impedes or stalls wound repair and regeneration | 367 |
Role of protease in wound infection | 369 |
Emerging uses of protease therapy | 373 |
References | 399 |
Nutrition and diabetic wound healing | 403 |
Dysregulated wound inflammation during diabetes | 404 |
Other nutritional interventions | 407 |
A natural remedy for diabetic wounds | 408 |
Conclusion | 410 |
345 | 411 |
Nanotechnology and nanocarriers in wound healing | 415 |
Drugdelivery nanocarriers for skin woundhealing applications | 439 |
175 | 473 |
References | 478 |
197 | 480 |
Potential biomarkers for improved | 491 |
Classification of bacterial VOCs by functional groups | 498 |
10 | 504 |
Further reading | 512 |
Novel concepts in diabetic wound healing | 513 |
Tissue regeneration and reprogramming | 515 |
Cells of tissue regeneration | 517 |
Role of ECM in tissue regeneration | 521 |
Epigenetics of tissue regeneration | 523 |
198 | 524 |
Conclusion | 525 |
Bone marrow monopoiesis and wound healing in diabetes | 535 |
MoMϕ dysregulation and impaired wound healing in diabetes | 537 |
Ontogeny of tissue mononuclear phagocytes and blood Mo in homeostasis | 538 |
Origin of wound Mϕ | 539 |
Tissue injury and monopoiesis | 541 |
Diabetesinduced HSPC modifications | 542 |
Potential mechanisms underlying HSPC alterations in diabetic bone marrow | 543 |
Signaling pathways involved in obesity and diabetesassociated increases in monopoiesis | 544 |
Effect of diabetes on skin woundinginduced monocyte expansion in bone marrow | 545 |
Conclusions implications and future directions | 547 |
Funding | 548 |
Role of mesenchymal stem cells in diabetic wound healing | 555 |
MicroRNAs in diabetes | 557 |
Wound healing | 579 |
587 | |
593 | |
594 | |
600 | |
607 | |
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Wound Healing, Tissue Repair, and Regeneration in Diabetes Debasis Bagchi,Amitava Das,Sashwati Roy Limited preview - 2020 |