Viral Vectors for Gene Therapy: Methods and Protocols

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Springer Science & Business Media, 2003 - Medical - 608 pages
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The promise of gene therapy can be realized only if workable vectors can be found to deliver therapeutic genes. In Viral Vectors for Gene Therapy: Methods and Protocols, leading researchers from academia and biotechnology describe proven molecular methods for the construction, development, and use of virus vectors for gene transfer and gene therapy. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system. Each protocol includes a discussion of the principles involved, numerous charts and tables, ample references, and notes on possible problems, troubleshooting, and alternative procedures. Comprehensive and highly practical, Viral Vectors for Gene Therapy: Methods and Protocols provides not only researchers with the basic tools needed to design targeted gene delivery vectors, but also clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders.
 

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Contents

I
1
II
33
III
51
IV
61
V
89
VI
113
VII
135
VIII
153
XVII
331
XVIII
343
XIX
353
XX
367
XXI
383
XXII
405
XXIII
433
XXIV
449

IX
167
X
201
XI
221
XII
237
XIII
255
XIV
269
XV
287
XVI
309
XXV
467
XXVI
493
XXVII
503
XXVIII
525
XXIX
545
XXX
565
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About the author (2003)

Machida, Oregon Health Sciences University, Beaverton.

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