Understanding the Process of Aging: The Roles of Mitochondria: Free Radicals, and AntioxidantsLester Packer This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the research of over 55 experts in the area, Understanding the Process of Aging Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines. |
Contents
The Mitochondrial Production of Oxygen Radicals and Cellular Aging | 1 |
Walking a Tightrope The Balance Between Mitochondrial Generation and Scavenging of Superoxide Anion | 17 |
The Biochemistry of Nitric Oxide and Peroxynitrite Implications for Mitochondrial Function | 39 |
OxygenDependent Regulation of Biological Functions by Nitric Oxide | 57 |
Production of Reactive Oxygen Species in Mitochondria and AgeAssociated Pathophysiology A Reality Check | 73 |
Functional Roles of Ubiquinone | 95 |
Mitochondrial Generation of Reactive Oxygen Species and Oxidative Damage During Aging Roles of Coenzyme Q and Tocopherol | 119 |
Mitochondria and Aging The Mouses Tale | 143 |
The Role of Iron and Mitochondria in Aging | 203 |
The MitochondrialLysosomal Axis Theory of Cellular Aging | 229 |
Quantitative Analysis of Mutations of Mitochondrial DNA During Human Aging | 251 |
Oxidative Damage and Fragility of Mitochondrial DNA | 265 |
Mitochondria in Cellular Aging and Degeneration | 293 |
Mitochondrial Alteration in Aging and Inflammation A Possible Site of Action of NitroneBased Free Radical Traps | 311 |
Muscle Mitochondrial Transmembrane Processes in Mitochondriocytopathies | 327 |
| 361 | |
Mitochondria and Apoptosis | 167 |
Role of Mitochondria in Oxidative Stress Associated with Aging and Apoptosis Studies in Intact Cells | 181 |
Other editions - View all
Common terms and phrases
Acad Sci USA accumulation acid aconitase activity age-related anion antimycin antioxidant apoptosis apoptotic Arch Biochem Biophys Biochem Biophys Res Biochim Biophys Acta Biol Chem Biophys Res Commun Boveris brain Ca2+ carrier catalase cell death cellular chondrial complex concentration cytochrome c oxidase cytosolic decreased deficiency deletions disease drial effect electron transport chain enzymes FEBS Lett Free Radic Biol gene genetic glutathione H₂O₂ heart mitochondria human hydrogen peroxide hyperoxia increase induced inhibition iron isolated lipid peroxidation lipofuscin liver mitochondria lysosomal mammalian Mech Ageing Dev mechanism membrane potential metabolism mice mito mitochon mitochondrial DNA mitochondrial function mitochondrial respiration Mn-SOD molecular mtDNA NADH Natl Acad Sci nitric oxide O₂ production oxidative damage oxidative stress permeability transition peroxidase Proc Natl Acad protein rat liver reaction reactive oxygen species redox reduced respiratory chain role scavenging skeletal muscle Sohal studies substrate superoxide dismutase tion tissues ubiquinone vivo wild-type yeast