Endotoxins: Pyrogens, LAL Testing and Depyrogenation

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Kevin L. Williams
Taylor & Francis, Feb 23, 2007 - Medical - 440 pages
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This source expertly examines the discovery, biological structure, control, and continued clarification of endotoxin from a parenteral manufacturing perspective, with in-depth discussion of state-of-the-art technologies involving Limulus amebocyte lysate (LAL) such as assay development, automation, depyrogenation. Completely revised and expanded, this Third Edition contains the knowledge necessary to apply endotoxin testing in the increasingly complex pharmaceutical environment, featuring sections detailing the latest information regarding clinical advances, regulation standards, and validation procedures for computerized kinetic tests.

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Endotoxin Relevance and Control Overview
J Fever and the Host Response
4 Endotoxin Structure Function and Activity

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