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adverse events adverse reactions ApoE artery disease assessment associated atherosclerosis atorvastatin bleeding bypass graft CABG Calgary Canada Canadian Cardiovascular Society Cardiac EASE Cardiol Cardiology cardiomyopathy cardiovascular disease CHAMPIX cholesterol clinical trials clopidogrel computed tomography CONTRAINDICATIONS coronary angiography coronary artery bypass CRESTOR decreased diagnosis discontinued disorders dosage dose dronedarone drug Edmonton effect elevation evaluation function genes guidelines heart failure hepatic hospital hypercholesterolemia hypertension increased interaction ischemic joumal LDL-C levels lipid LIPITOR MDCT metabolic syndrome metformin mice mmol/L Montreal myocardial infarction myopathy olmesartan medoxomil Ontario Ottawa patients pediatric percutaneous coronary intervention physicians placebo plaque plasma PLAVIX population potential present Product Monograph protein Pulsus rats receptor recommended reduce reductase inhibitors renal impairment reported revascularization risk factors rosuvastatin significant sitagliptin stenosis stent Supplemental Product Information surgery symptoms therapy Toronto treatment varenicline versus WARNINGS AND PRECAUTIONS