Stereochemistry of Radical Reactions: Concepts, Guidelines, and Synthetic Applications
As little as a decade ago, radicals were regarded as interesting reactive intermediates with little synthetic use. However, recent results show that radicals have an enormous potential for applications in stereoselective reactions - it's all a matter of knowing what method to use and how to apply it.
Three world experts in the field have combined their expertise and present the concepts to understand and even to predict the course of stereoselective radical reactions. In addition, guidelines are established which will enable the readers to plan and carry out their own stereoselective syntheses with radicals. A comprehensive list of references provides an easy access to the primary literature.
The Stereochemistry of Radical Reactions is a highly topical introduction to this burgeoning field of research. Both advanced students and researchers active in the field will welcome this book as a source of concepts and ideas.
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Radical Reactions in Organic Synthesis
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acyclic addition reactions alkene alkyl allyl amide analogous atom attack auxiliary group axial bearing bond BuzSnH calculations carbon carbonyl CH3 CH3 chair Chapter Chem chiral auxiliary CO2Et CO2Me compared configuration conformation coupling D. P. Curran depends derived diastereomer diastereoselection effects energy enolate Equation equatorial ester example expected face favored Figure formation formed free radical geometry Giese gives hexenyl radical hydrogen important increases intermediate involving isomer leads major method methyl mixture observed occur organic orientation oxygen pair possible precursor predicts preferred present prostereogenic radical addition radical cyclizations radical reactions ratio rearrangement relative requires ring selectivity shielding shown shows similar simple species step stereochemistry stereogenic center stereoisomer stereoselectivity structure studies substituent substrates suggests sultam synthesis temperature Tetrahedron Lett trans transfer transition trapping types yield