Materials and Strategies for Lab-on-a-Chip - Biological Analysis, Cell-Material Interfaces and Fluidic Assembly of Nanostructures: Volume 1191Sashi K. Murthy, Saif A. Khan, Victor M. Ugaz, Henry C. Zeringue The development of miniaturized systems for chemical and biochemical analysis has grown to the point where lab-on-a-chip devices are now important enabling tools in a diverse array of application areas. As the size of these systems continues to shrink, details of the micro- and nanoscale phenomena associated with their construction and operation must be considered. This book focuses on materials and engineering aspects of lab-on-a-chip devices and the application of microfluidics to materials synthesis. A microfabricated fluidic system integrating biological sample treatment and detection on a single chip offers the promise of low-cost, rapid and high-performance analysis. These devices can perform high-throughput biochemical assays for drug discovery and provide portability for point-of-care diagnostics and biothreat monitoring. Topics include: frontiers in lab-on-a-chip research; materials for lab-on-a-chip; materials synthesis on chip; cell manipulation and biomimetics on chip; porous materials in lab-on-a-chip; sensing and detection on chip - molecular level; sensing and detecting on chip - cells and particles; and sensing and detection on chip - DNA. |
Contents
ScreenGrid Field Effect Transistor for Sensing | 127 |
Resonant Microcavities Coupled to a Photonic | 133 |
PhosphateDependent DNA Immobilization | 141 |
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2009 Materials Research antibody apertures array BChl bio-imaging Biosensors capacitance CC-FET chip chitosan chlorosomes chondrocytes coating concentration contact angle deposited detection diameter droplet dry film resist electrochemical cells electrode embossed depth etching fabrication Fe nanowires Field Effect Transistor flow rate fluid fluorescence gate geometry HfO2 hot embossing hybridization immobilization immunoassays increased injection integrated interface ISBN Lab-on-a-Chip layer lipid bilayer lithographic magnetic Materials Research Society measured membranes method micro microcavities microchannel microfluidic mold insert molecules nanoparticles nanopore nanopore device nanostructure nanowires norbornene optical oxide parameters particles pattern PCTE PDMS phosphate photodiode photonic photonic crystal Plasma Electrolytic Oxidation PMMA polymer pore probe Proc protein range replication sample sensor SGrFET shear shows silica silicon simulations solution SPM film structure substrate surface Symp Technology thickness transition temperature transparency masks voltage Volume wafer waveguide wavelength width