Oncogenomics: Molecular Approaches to Cancer
Charles Brenner, David Duggan
Wiley, Mar 29, 2004 - Medical - 394 pages
This book aims to assemble the only available rigorous, yet broadly accessible introduction to this new and exciting field. Oncogenomics: Molecular Approaches to Cancer is approachable by basic scientists, practitioners, and other health professionals required to familiarize themselves with the tremendous impact of genomics and proteomics on cancer research. Clearly written chapters offer reviews of state of the art topics such as molecular classification, early detection, SNPs in cancer, data mining, tissue microarrays, protein and antibody arrays, and drug targets.
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AT THE PRECARIOUS CUSP OF ONCOGENOMICS
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Acad Sci USA activity adenomatous polyposis alleles amplification analysis antibody APC gene apoptosis approach array Biol biological BRCA1 BRCA2 breast cancer Cancer Res carcinomas cDNA cDNA microarrays Celis cellular Chapter Chem chromosome clinical clones cluster colon colorectal cancer comparative genomic hybridization copy number changes database deletions detection disease drug epithelial expression patterns expression profiling familial adenomatous polyposis farnesyltransferase farnesyltransferase inhibitors FTIs function gene expression genome-wide genotype growth haplotypes high-throughput homozygous human cancer human genome identify inhibition inhibitors K-Ras Kallioniemi kinase leukemia locus lymphomas malignant mammary mapping markers molecular profiling molecules mouse models multiple mutations Nat Genet Natl Acad Sci neoplasia normal oncogene Oncogenomics overexpression pathway patients phenotype polyp polyp number prenylation Proc Natl Acad protein proteomic PTEN receptor region RhoB samples screening sequence SNPs specific studies subtypes susceptibility target therapy tissue tissue microarray transgenic transgenic mice tumor cells tumor suppressor genes tumorigenesis types