Immunology of Breast Milk: A Monograph of the National Institute of Child Health and Human DevelopmentPearay L. Ogra, Delbert H. Dayton Abstract: The mechanisms of immunity transfer to newborns through breast milk are not clearly understood. Biochemists exchanged information relevant to the systemic and local muscosal immunity system provided to the newborn by the mammary gland and its secretions. Topics include the functions of the mucosal immune system and the gut-associated and bronchial-associated lymphoid tissues, the transfer of maternal antibodies to fetus or newborn, andthe constituents of human colostrum and milk, such as immunoglobulins M, G, A, E and D, and cells B, T, NK and K. Questions which remain unanswered include stimulus and location of B-cell switching; the origin and acquisition of T-cell recognition patterns; cell migration and binding; maternal cell colonization of the infant; the presence of lymphokines and monokines; and the roles of basophils, most cells and esinophils. |
Contents
TCell Regulation of IgA Synthesis | 37 |
Immunological Unresponsiveness after Enteric Administration of Protein | 49 |
Induction and Dissemination of an Intestinal Immune Response to Cholera | 63 |
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animals antibody antibody response antigen ASHERSON BEER BIENENSTOCK blasts blood lymphocytes bronchial CEBRA cellular cholera toxin coli colostrum colostrum and milk contact sensitivity contact-sensitizing agents cytotoxic DNA synthesis donor dose effect epithelial cells epithelium feeding gastrointestinal HANSON human colostrum human milk IgA antibodies IgA precursors IgA response immune response immunoglobulin Immunol immunologic induced infants infection isotype lactation lamina propria LAMM leukocytes lymph nodes lymphoblasts lymphoid cells lymphoid tissue macrophages mammary gland maternal mesenteric lymph node mesenteric node mice migration milk lymphocytes mothers mouse mucosal mucosal follicles neonatal newborn observed Ogra oral oxazolone parenteral PARMELY PARROTT Peyer's patches pigs plasma cells population PORTER priming protein rabbit rats reactivity receptors recipients secretions secretory component secretory IgA serum sIgA small intestine sows specific spleen stimulation STROBER studies suckling suggest suppression suppressor cells T-cell titers toxoid tract transfer unresponsiveness vaccination virus vitro WAKSMAN