Self and Nonself
Springer Science & Business Media, Mar 7, 2012 - Medical - 320 pages
In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.
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CHAPTER 2 THE EVOLUTION OF SELF DURING THE TRANSITION TO MULTICELLULARITY
CHAPTER 3 GLYCONECTIN GLYCANS AS THE SELFASSEMBLING NANOMOLECULARVELCROSYS TEMMEDIATING SELFNONSELFRE...
CHAPTER 4 NEGLECTED BIOLOGICAL FEATURES IN CNIDARIANS SELFNONSELF RECOGNITION
CHAPTER 5 INTRACELLULAR INFLAMMATORY SENSORS FOR FOREIGN INVADERS AND SUBSTANCES OF SELFORIGIN
CHAPTER 6 NONSELF PERCEPTION IN PLANT INNATE IMMUNITY
CHAPTER 7 HOW DID FLOWERING PLANTS LEARN TO AVOID BLIND DATE MISTAKES?
Evolution of Apoptosis in the Context of SelfDefense
CHAPTER 11 AUTOPHAGY AND SELFDEFENSE
VirusMediated Self Identity
CHAPTER 13 THE EVOLUTION OF ADAPTIVE IMMUNITY
CHAPTER 14 EPIGENETIC CODE AND SELFIDENTITY
Usurping Host Genes as a Survival Strategy
CHAPTER 16 THE EMERGENCE OF THE MAJOR HISTOCOMPATILIBILITY COMPLEX
CHAPTER 17 MHC SIGNALING DURING SOCIAL COMMUNICATION
CHAPTER 9 SENSING NECROTIC CELLS
CHAPTER 10 SENSING ENDOPLASMIC RETICULUM STRESS
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Acad Sci USA acid activation adaptive immune system addiction module adhesion antigen apoptosis apoptosome apoptotic ATF6 autophagy bacterial binding Biol biology caspase-1 caspases cell death cellular chemokine cnidarians colonization complex CRISPR cytomegalovirus differentiation effector encoded epigenetic eukaryotic evolution evolutionary expression extracellular FHOO FHOOV flagellin function genes genetic genome glycan glyconectin group identity HCMV homolog host human immune response Immunol individual induce infection inflammasome inhibits innate immunity interactions involved IRE1 Ire1p KDYH kinase ligands LQ WKH mechanisms mediated membrane MHC class mice modules molecular molecules multicellular mutations Natl Acad Sci nonself organisms pathogens pathway peptides phage Plant pollen Proc Natl Acad prokaryotes recognition region regulation RI WKH role S-RNase self-incompatibility self-nonself sequence signaling somatic specific Springer Science+Business Media structure Toll-like receptor transcription transcription factor types unfolded protein vertebrates viral virus viruses VSHFL¿F WKDW WKLV ZKLFK ZLWK