Self and Nonself

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Carlos López-Larrea
Springer Science & Business Media, Mar 7, 2012 - Medical - 320 pages
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In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.
 

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Contents

CHAPTER 1 THE ORIGIN OF THE BACTERIAL IMMUNE RESPONSE
1
CHAPTER 2 THE EVOLUTION OF SELF DURING THE TRANSITION TO MULTICELLULARITY
14
CHAPTER 3 GLYCONECTIN GLYCANS AS THE SELFASSEMBLING NANOMOLECULARVELCROSYS TEMMEDIATING SELFNONSELFRE...
31
CHAPTER 4 NEGLECTED BIOLOGICAL FEATURES IN CNIDARIANS SELFNONSELF RECOGNITION
46
CHAPTER 5 INTRACELLULAR INFLAMMATORY SENSORS FOR FOREIGN INVADERS AND SUBSTANCES OF SELFORIGIN
60
CHAPTER 6 NONSELF PERCEPTION IN PLANT INNATE IMMUNITY
79
CHAPTER 7 HOW DID FLOWERING PLANTS LEARN TO AVOID BLIND DATE MISTAKES?
108
Evolution of Apoptosis in the Context of SelfDefense
124
CHAPTER 11 AUTOPHAGY AND SELFDEFENSE
169
VirusMediated Self Identity
185
CHAPTER 13 THE EVOLUTION OF ADAPTIVE IMMUNITY
218
CHAPTER 14 EPIGENETIC CODE AND SELFIDENTITY
236
Usurping Host Genes as a Survival Strategy
256
CHAPTER 16 THE EMERGENCE OF THE MAJOR HISTOCOMPATILIBILITY COMPLEX
277
CHAPTER 17 MHC SIGNALING DURING SOCIAL COMMUNICATION
290
INDEX
315

CHAPTER 9 SENSING NECROTIC CELLS
144
CHAPTER 10 SENSING ENDOPLASMIC RETICULUM STRESS
153

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About the author (2012)

Carlos López-Larrea is Professor of Immunology (Oviedo, Spain) and currently Head of the Department of Immunology at the Hospital Universitario Central de Asturias (Oviedo, Spain). He is a world expert on spondyloarthropathies (SpA), in particular genetic (MHC) and genetic factors that influence the development of the disease. The main research interests of his group also currently include the study of epigenetic mechanisms involved in autoimmune diseases and the role of innate immunity in organ transplantation tolerance. He is a member of several international scientific organizations and board member of different scientific journals. He has published more than 150 international papers and books related to immunology and spondylaorthropathies.

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