Research in the Biomedical Sciences: Transparent and Reproducible

Front Cover
Michael Williams, Michael Curtis, Kevin Mullane
Academic Press, Oct 20, 2017 - Science - 382 pages

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting.

The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved.

This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.

  • Provides a “big picture perspective on the scope of reproducibility issues and covers initiatives that have potential as effective solutions
  • Offers real-world research context for transparent, reproducible experimental design, execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery
  • Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability
 

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Contents

Chapter 2 Experimental Planning and Execution
67
Chapter 3 Statistical Analysis in Preclinical Biomedical Research
107
Chapter 4 Reporting Results
145
Peer Review Impact Factors Checklists Guidelines and Reproducibility Initiatives
197
Multiple Challenges in Resolving Reproducibility Issues
307
Index
355
Back Cover
371
Copyright

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About the author (2017)

Michael Williams is an Adjunct Professor of Pharmacology with the Feinberg School of Medicine, Northwestern University in Chicago, IL, USA

Michael Curtis is a Reader in Pharmacology, King’s College London, Rayne Institute, St. Thomas’ Hospital, London, UK

Kevin Mullane is Director, Corporate Liaison and Ventures with J. David Gladstone Institutes, University of California, San Francisco in San Francisco, CA

Bibliographic information