Research in the Biomedical Sciences: Transparent and Reproducible

Front Cover
Michael Williams, Michael Curtis, Kevin Mullane
Academic Press, Oct 20, 2017 - Science - 382 pages

Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting.

The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved.

This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences.

  • Provides a “big picture perspective on the scope of reproducibility issues and covers initiatives that have potential as effective solutions
  • Offers real-world research context for transparent, reproducible experimental design, execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery
  • Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability
 

Selected pages

Contents

Chapter 2 Experimental Planning and Execution
67
Chapter 3 Statistical Analysis in Preclinical Biomedical Research
107
Chapter 4 Reporting Results
145
Peer Review Impact Factors Checklists Guidelines and Reproducibility Initiatives
197
Multiple Challenges in Resolving Reproducibility Issues
307
Index
355
Back Cover
371
Copyright

Common terms and phrases

academic analysis animal models antibodies assay assessment authors Available Begley bias biological biomedical research biotech blog cancer cell lines Chapter checklists citation clinical trials compound data set database discussed disease drug discovery editors effect ensure ethical example experimental design experiments feedback findings fraud funding gene genetic grant guidelines h-index healthcare human identified Impact Factor improve individual initiatives institutions involved Ioannidis irreproducibility issues journals laboratory lack literature measure methods metrics MMR vaccine Mullane multiple multiple comparisons Nature negative normal null hypothesis original outcomes p-value paper patients peer review peer review process Pharmacol Pharmacology phenotype PLoS potential PPPR preclinical research protein publication publication bias published randomization relevance replication reported reproducibility response retracted RNA interference sample scientific scientists selective significance standard statistical statistical power submission target tion transparency validation variability

About the author (2017)

Michael Williams is an Adjunct Professor of Pharmacology with the Feinberg School of Medicine, Northwestern University in Chicago, IL, USA

Michael Curtis is a Reader in Pharmacology, King’s College London, Rayne Institute, St. Thomas’ Hospital, London, UK

Kevin Mullane is Director, Corporate Liaison and Ventures with J. David Gladstone Institutes, University of California, San Francisco in San Francisco, CA

Bibliographic information

QR code for Research in the Biomedical Sciences
TitleResearch in the Biomedical Sciences: Transparent and Reproducible
EditorsMichael Williams, Michael Curtis, Kevin Mullane
Editionillustrated
PublisherAcademic Press, 2017
ISBN0128047267, 9780128047262
Length382 pages
Subjects ›  › 

Medical / Physiology
Science / Life Sciences / Biochemistry
Science / Life Sciences / Human Anatomy & Physiology
Science / Life Sciences / Molecular Biology
  
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