Purine and Pyrimidine Metabolism in Man V: Part B: Basic Science AspectsW. L. Nyhan, Linda Frances Thompson, R. W. E. Watts The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U. S. A. ) in July and August of 1985. Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum. The next meeting will be in Japan. This Symposium differed from those that went before in that it per mitted us to honor Dr. J. E. Seegmiller, Professor of Medicine at the University of California San Diego, for his many contributions to our understanding of purine metabolism in man. This publication is dedicated as a Festschrift to Jay. Dr. Richard W. E. Watts delivered the keynote address outlining in scholarly fashion the history of Dr. Seegmiller's accomplishments in research on purine metabolism and the great number of currently active scientists in this field who have worked with him. This address is published as the first contribution to Volume I. Dr. Dewitt Stetten, Jr. , was scheduled to be the speaker at our banquet. Unfortunate ly, he could not be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our field, and this has been pub lished following Dr. Watts' paper. The growth of knowledge in purine and pyrimidine metabolism continues to be exponential. The variety of subjects included in these volumes is impressive. |
Contents
I | 1 |
An Appreciation of DeWitt Stetten | 11 |
Detection of Inherited Adenylosuccinase Deficiency by Two | 21 |
Copyright | |
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Purine and Pyrimidine Metabolism in Man V: Part B: Basic Science Aspects W. L. Nyhan No preview available - 1986 |
Common terms and phrases
acetazolamide ADA activity ADA deficiency adenine adenosine deaminase allopurinol ara-A assay Bartter's syndrome Biochem Biol blood bound uric acid bumetanide catabolism cell lines Chem chromatography clearance Clin clinical creatinine cultured dAdo dATP defect deoxy deoxyadenosine deoxyguanosine dGuo diet disease dose effect enzyme enzyme activity erythrocytes fibroblasts gene gout gouty patients guanosine heterozygotes HGPRT HPLC HPRT human hyperuricemia hypoxanthine immunodeficiency increased incubation inhibition inhibitor inosine intracellular J.E. Seegmiller Lesch-Nyhan syndrome lymphoblasts lymphocytes lymphoid method mg/dl MSU crystals mutant normal nucleotide orotic orotic acid oxidase oxipurinol oxypurine phosphoribosyltransferase plasma PMNs probenecid protein PRPP PRPP synthetase purine and pyrimidine purine metabolism purine nucleoside phosphorylase pyrimidine samples serum urate concentration serum urate levels serum uric acid studies subjects substrate synthesis Table therapy toxicity treatment urate binding urate excretion urate oxidase uric acid uric acid excretion urinary urine vitro xanthine